RXN-8675

Reaction RXN-8675

• direction:
  • LEFT-TO-RIGHT
• common name:
  • S-adenosyl-L-methionine:precorrin-1 C-methyltransferase
• Synonym(s):
  • uroporphyrinogen methyltransferase
  • uroporphyrinogen-III methyltransferase
  • adenosylmethionine-uroporphyrinogen III methyltransferase
  • S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase
  • SirA
  • CysG
  • uroporphyrin-III C-methyltransferase (incorrect)
  • S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase (incorrect)

Reaction Formula

• With identifiers:
  • 1 S-ADENOSYLMETHIONINE[c] + 1 CPD-9038[c] => 1 ADENOSYL-HOMO-CYS[c] + 1 DIHYDROSIROHYDROCHLORIN[c]
• With common name(s):
  • 1 S-adenosyl-L-methionine[c] + 1 precorrin-1[c] => 1 S-adenosyl-L-homocysteine[c] + 1 precorrin-2[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: g6155.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-ectocarpus_siliculosus
  • Source: orthology-saccharina_japonica

Pathways

• PWY-5194, siroheme biosynthesis: PWY-5194
  • 4 reactions found over 4 reactions in the full pathway
• PWY-7377, cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion): PWY-7377
  • 4 reactions found over 15 reactions in the full pathway
• PWY-7376, cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation): PWY-7376
  • 2 reactions found over 13 reactions in the full pathway
• PWY-5196, factor 430 biosynthesis: PWY-5196
  • 3 reactions found over 7 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-saccharina_japonica
    • Tool: pantograph
  • Source: orthology-ectocarpus_siliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-cladosiphon_okamuranus
    • Tool: pathwaytools

External links

• RHEA:
  • 21973
• LIGAND-RXN:
  • R07238