3-ISOPROPYLMALISOM-RXN

Reaction 3-ISOPROPYLMALISOM-RXN

• direction:
  • REVERSIBLE
• common name:
  • 3-isopropylmalate dehydratase
  • (2S)-2-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
• Synonym(s):
  • (2R,3S)-3-isopropylmalate hydro-lyase
  • β-isopropylmalate dehydratase
  • α-isopropylmalate isomerase
  • 3-isopropylmalate hydro-lyase

Reaction Formula

• With identifiers:
  • 1 CPD-9451[c] + 1 WATER[c] <=> 1 3-CARBOXY-3-HYDROXY-ISOCAPROATE[c]
• With common name(s):
  • 1 2-isopropylmaleate[c] + 1 H2O[c] <=> 1 (2S)-2-isopropylmalate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: g9335.t1
  • Source: orthology-ectocarpus_siliculosus
  • Source: orthology-nannochloropsis_salina
  • Source: orthology-arabidopsis_thaliana
  • Source: orthology-saccharina_japonica
• Gene: g18076.t1
  • Source: orthology-ectocarpus_siliculosus
  • Source: orthology-nannochloropsis_salina
  • Source: orthology-arabidopsis_thaliana
  • Source: orthology-saccharina_japonica
• Gene: g9421.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-ectocarpus_siliculosus
  • Source: orthology-nannochloropsis_salina
  • Source: orthology-arabidopsis_thaliana
• Gene: g9335.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g18076.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER

Pathways

• LEUSYN-PWY, L-leucine biosynthesis: LEUSYN-PWY
  • 5 reactions found over 6 reactions in the full pathway
• PWY-6871, 3-methylbutanol biosynthesis (engineered): PWY-6871
  • 5 reactions found over 7 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-saccharina_japonica
    • Tool: pantograph
  • Source: orthology-ectocarpus_siliculosus
    • Tool: pantograph
  • Source: orthology-nannochloropsis_salina
    • Tool: pantograph
  • Source: orthology-arabidopsis_thaliana
    • Tool: pantograph
• Category: annotation
  • Source: annotation-cladosiphon_okamuranus
    • Tool: pathwaytools

External links

• UNIPROT:
  • Q9PLW1
  • Q9JU82
  • P80858
  • Q9UZ07
  • Q9JU81
  • Q58673
  • Q02144
  • P44968
  • Q58667
  • P44438
  • P0A6A6
  • Q9PLW2
  • Q44022
  • Q44023
  • Q44427
  • P17279
  • P04787
  • P15717
  • P18250
  • Q02142
  • P30126
  • P50181
  • P07264
  • P74207
  • O86534
  • O86535
• RHEA:
  • 16296
• LIGAND-RXN:
  • R03968