ARACHIDONATE-5-LIPOXYGENASE-RXN

Reaction ARACHIDONATE-5-LIPOXYGENASE-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • arachidonate 5-lipoxygenase
• Synonym(s):
  • leukotriene-A4 synthase
  • Δ5-lipoxygenase
  • 5Δ-lipoxygenase
  • arachidonic 5-lipoxygenase
  • arachidonic acid 5-lipoxygenase
  • C-5-lipoxygenase
  • LTA synthase
  • leukotriene A4 synthase

Reaction Formula

• With identifiers:
  • 1 OXYGEN-MOLECULE[c] + 1 ARACHIDONIC_ACID[c] => 1 6E8Z11Z14Z-5S-5-HYDROPEROXYCOSA-6[c]
• With common name(s):
  • 1 oxygen[c] + 1 arachidonate[c] => 1 (5S)-HPETE[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: g6085.t1
  • Source: orthology-saccharina_japonica
• Gene: g11424.t1
  • Source: orthology-saccharina_japonica
• Gene: g12029.t2
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g12029.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER

Pathways

• PWY66-375, leukotriene biosynthesis: PWY66-375
  • 5 reactions found over 6 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-saccharina_japonica
    • Tool: pantograph
• Category: annotation
  • Source: annotation-cladosiphon_okamuranus
    • Tool: pathwaytools

External links

• UNIPROT:
  • P12527
  • P09917
  • Q7M0C1
• RHEA:
  • 17486
• LIGAND-RXN:
  • R01595