PROGESTERONE-5-ALPHA-REDUCTASE-RXN

Reaction PROGESTERONE-5-ALPHA-REDUCTASE-RXN

• ec number:
  • EC-1.3.1.22
• direction:
  • LEFT-TO-RIGHT
• common name:
  • progesterone 5α-reductase
• Synonym(s):
  • steroid 5-α-reductase
  • Δ4-steroid 5α-reductase (progesterone)

Reaction Formula

• With identifiers:
  • 1 PROGESTERONE[c] + 1 NADPH[c] + 1 PROTON[c] => 1 CPD-293[c] + 1 NADP[c]
• With common name(s):
  • 1 progesterone[c] + 1 NADPH[c] + 1 H+[c] => 1 5-α-pregnane-3,20-dione[c] + 1 NADP+[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: g4721.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-saccharina_japonica
• Gene: g12550.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g9244.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g9245.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER

Pathways

• PWY-7455, allopregnanolone biosynthesis: PWY-7455
  • 1 reactions found over 2 reactions in the full pathway
• PWY-6032, cardenolide biosynthesis: PWY-6032
  • 1 reactions found over 3 reactions in the full pathway

Reconstruction information

• Category: annotation
  • Source: annotation-cladosiphon_okamuranus
    • Tool: pathwaytools
• Category: orthology
  • Source: orthology-saccharina_japonica
    • Tool: pantograph

External links

• RHEA:
  • 21954
• LIGAND-RXN:
  • R02208