RXN-12705

Reaction RXN-12705

• ec number:
  • EC-1.1.1.35
• direction:
  • LEFT-TO-RIGHT
• common name:
  • 3-hydroxyacyl-CoA dehydrogenase
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 CPD-13694[c] + 1 NAD[c] => 1 CPD-13695[c] + 1 NADH[c] + 1 PROTON[c]
• With common name(s):
  • 1 24-hydroxy-3-oxocholest-4-en-26-oyl-CoA[c] + 1 NAD+[c] => 1 3,24-dioxocholest-4-en-26-oyl-CoA[c] + 1 NADH[c] + 1 H+[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: g12553.t1
  • Source: orthology-saccharina_japonica
• Gene: g3371.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-ectocarpus_siliculosus
  • Source: orthology-saccharina_japonica
• Gene: g7899.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: GO-TERM
  • Source: orthology-saccharina_japonica
• Gene: g17267.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: GO-TERM
  • Source: orthology-saccharina_japonica
• Gene: g3370.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g10833.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-saccharina_japonica
• Gene: g10495.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: GO-TERM
  • Source: orthology-saccharina_japonica
• Gene: g10495.t2
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-saccharina_japonica
• Gene: g3527.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: GO-TERM
  • Source: orthology-saccharina_japonica
• Gene: g14423.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: GO-TERM
  • Source: orthology-saccharina_japonica

Pathways

• PWY-6946, cholesterol degradation to androstenedione II (cholesterol dehydrogenase): PWY-6946
  • 4 reactions found over 22 reactions in the full pathway
• PWY-6945, cholesterol degradation to androstenedione I (cholesterol oxidase): PWY-6945
  • 3 reactions found over 17 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-saccharina_japonica
    • Tool: pantograph
  • Source: orthology-ectocarpus_siliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-cladosiphon_okamuranus
    • Tool: pathwaytools