1.1.1.34-RXN

Reaction 1.1.1.34-RXN

• direction:
  • REVERSIBLE
• common name:
  • hydroxymethylglutaryl-CoA reductase (NADPH)
  • Hydroxymethylglutaryl-CoA reductase, class I/II
  • Hydroxymethylglutaryl-CoA reductase, N-terminal
• ec number:
  • EC-1.1.1.34
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 MEVALONATE[c] + 2 NADP[c] + 1 CO-A[c] <=> 2 PROTON[c] + 1 3-HYDROXY-3-METHYL-GLUTARYL-COA[c] + 2 NADPH[c]
• With common name(s):
  • 1 (R)-mevalonate[c] + 2 NADP+[c] + 1 coenzyme A[c] <=> 2 H+[c] + 1 (S)-3-hydroxy-3-methylglutaryl-CoA[c] + 2 NADPH[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Ec-03_000570
  • Source: annotation-esiliculosus_genome
    • Assignment: EC-NUMBER
  • Source: orthology-aragem
• Gene: Ec-03_000580
  • Source: annotation-esiliculosus_genome
    • Assignment: EC-NUMBER
• Gene: Ec-08_002990
  • Source: annotation-esiliculosus_genome
    • Assignment: EC-NUMBER
  • Source: orthology-aragem
• Gene: Ec-27_005710
  • Source: annotation-esiliculosus_genome
    • Assignment: GO-TERM

Pathways

• PWY-922, mevalonate pathway I: PWY-922
  • 7 reactions found over 7 reactions in the full pathway
• PWY-6174, mevalonate pathway II (archaea): PWY-6174
  • 5 reactions found over 7 reactions in the full pathway
• PWY-7391, isoprene biosynthesis II (engineered): PWY-7391
  • 7 reactions found over 8 reactions in the full pathway
• PWY-7524, mevalonate pathway III (archaea): PWY-7524
  • 4 reactions found over 8 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-aragem
    • Tool: pantograph
• Category: annotation
  • Source: annotation-esiliculosus_genome
    • Tool: pathwaytools

External links

• RHEA:
  • 15989
• LIGAND-RXN:
  • R02082
• UNIPROT:
  • P16393
  • P14891
  • P16237
  • P20715
  • Q59468
  • Q01237
  • Q61671
  • Q944T9
  • Q9S9C2
  • Q9S999
  • Q9S998
  • Q9S997
  • P04035
  • P00347
  • P29058
  • P29057
  • Q12577
  • Q12649
  • Q00583
  • Q01559
  • P48022
  • Q43825
  • Q43826
  • P14773
  • Q7M4W2
  • Q7M4W1
  • Q7M4W4
  • Q7M4W3
  • P48019
  • Q41454
  • Q42506
  • Q41455
  • Q41456
  • Q41458
  • P48020
  • Q9FS01
  • Q42466
  • O48624
  • O04188
  • O24594
  • Q41438
  • O64966
  • O64967
  • Q03163
  • Q39628
  • P93514
  • O08424