NNATr

Reaction MTHFD

• direction:
  • REVERSIBLE
• common name:
  • Methylenetetrahydrofolate dehydrogenase (NADP)
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1.0 mlthf[c] + 1.0 nadp[c] <=> 1.0 nadph[c] + 1.0 methf[c]
• With common name(s):
  • 1.0 5,10-Methylenetetrahydrofolate[c] + 1.0 Nicotinamide adenine dinucleotide phosphate[c] <=> 1.0 Nicotinamide adenine dinucleotide phosphate - reduced[c] + 1.0 5,10-Methenyltetrahydrofolate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• EF0978
  • pantograph-l_plantarum_wcfs1
  • pantograph-e_coli_sstr_k12_substr_mg1655
  • pantograph-b_subtilis_subsp_subtilis_str168

Pathways

• map01100: map01100
  • 508 reactions found over 2349 reactions in the full pathway
• map01200: map01200
  • 50 reactions found over 220 reactions in the full pathway
• map00670: map00670
  • 14 reactions found over 65 reactions in the full pathway
• map01120: map01120
  • 111 reactions found over 715 reactions in the full pathway
• map00720: map00720
  • 17 reactions found over 157 reactions in the full pathway

Reconstruction information

• orthology:
  • pantograph:
    • e_coli_sstr_k12_substr_mg1655
    • l_plantarum_wcfs1
    • b_subtilis_subsp_subtilis_str168

External links

• RHEA:
  • 22812
• MetaNetX (MNX) Equation : MNXR101749
• KEGG Reaction : R01220
• EC Number : 1.5.1.5