RXN66-306

Reaction RXN66-306

• direction:
  • LEFT-TO-RIGHT
• common name:
  • 14-demethyllanosterol Δ14 reductase
  • 4,4-dimethyl-5α-cholesta-8,24-dien-3β-ol:NADP+ Δ14-oxidoreductase
• ec number:
  • EC-1.3.1.70
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 44-DIMETHYL-CHOLESTA-812-24-TRIENOL[c] + 1 PROTON[c] + 1 NADPH[c] => 1 44-DIMETHYL-824-CHOLESTADIENOL[c] + 1 NADP[c]
• With common name(s):
  • 1 4,4-dimethyl-cholesta-8,12,24-trienol[c] + 1 H+[c] + 1 NADPH[c] => 1 4,4-dimethylzymosterol[c] + 1 NADP+[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: SJ12265
  • Source: annotation-saccharina_japonica_genome
    • Assignment: EC-NUMBER
  • Source: orthology-ectocarpus_siliculosus

Pathways

• PWY66-341, cholesterol biosynthesis I: PWY66-341
  • 14 reactions found over 22 reactions in the full pathway
• PWY-6074, zymosterol biosynthesis: PWY-6074
  • 6 reactions found over 12 reactions in the full pathway
• PWY66-4, cholesterol biosynthesis III (via desmosterol): PWY66-4
  • 14 reactions found over 22 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-ectocarpus_siliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-saccharina_japonica_genome
    • Tool: pathwaytools

External links

• LIGAND-RXN:
  • R05639