RXN-12626

Reaction 2-ISOPROPYLMALATESYN-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • 2-isopropylmalate_synthase_chloroplastic
• ec number:
  • EC-2.3.3.13
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 ACETYL-COA[c] + 1 2-KETO-ISOVALERATE[c] + 1 WATER[c] => 1 PROTON[c] + 1 3-CARBOXY-3-HYDROXY-ISOCAPROATE[c] + 1 CO-A[c]
• With common name(s):
  • 1 acetyl-CoA[c] + 1 3-methyl-2-oxobutanoate[c] + 1 H2O[c] => 1 H+[c] + 1 (2S)-2-isopropylmalate[c] + 1 coenzyme A[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Tiso_gene_11453
  • IN-SILICO_ANNOTATION
    • EC-NUMBER
  • EXPERIMENTAL_ANNOTATION
    • EC-NUMBER
  • pantograph-athaliana
  • pantograph-synechocystis
  • pantograph-esiliculosus
  • pantograph-creinhardtii

Pathways

• LEUSYN-PWY, L-leucine biosynthesis: LEUSYN-PWY
  • 6 reactions found over 6 reactions in the full pathway
• PWY-6871, 3-methylbutanol biosynthesis (engineered): PWY-6871
  • 6 reactions found over 7 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-athaliana
    • Tool: pantograph
  • Source: orthology-creinhardtii
    • Tool: pantograph
  • Source: orthology-synechocystis
    • Tool: pantograph
  • Source: orthology-esiliculosus
    • Tool: pantograph
• Category: manual
  • Source: manual-primary_network
• Category: annotation
  • Source: annotation-experimental_annotation
    • Tool: pathwaytools
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools

External links

• RHEA:
  • 21524
• LIGAND-RXN:
  • R01213
• UNIPROT:
  • P06208
  • Q58595
  • P09151
  • Q9PLV9
  • Q9JUK6
  • Q58787
  • P94565
  • Q9JP75
  • Q02141
  • P48575
  • O86511