RME298

Reaction 2.8.1.6-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • biotin_synthase
• ec number:
  • EC-2.8.1.6
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 Sulfurated-Sulfur-Acceptors[c] + 2 S-ADENOSYLMETHIONINE[c] + 2 Reduced-2Fe-2S-Ferredoxins[c] + 1 DETHIOBIOTIN[c] => 1 BIOTIN[c] + 2 CH33ADO[c] + 1 Unsulfurated-Sulfur-Acceptors[c] + 2 MET[c] + 2 Oxidized-2Fe-2S-Ferredoxins[c]
• With common name(s):
  • 1 a sulfurated [sulfur carrier][c] + 2 S-adenosyl-L-methionine[c] + 2 a reduced [2Fe-2S] ferredoxin[c] + 1 dethiobiotin[c] => 1 biotin[c] + 2 5'-deoxyadenosine[c] + 1 an unsulfurated [sulfur carrier][c] + 2 L-methionine[c] + 2 an oxidized [2Fe-2S] ferredoxin[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Tiso_gene_10345
  • IN-SILICO_ANNOTATION
    • AUTOMATED-NAME-MATCH
  • EXPERIMENTAL_ANNOTATION
    • AUTOMATED-NAME-MATCH
  • pantograph-esiliculosus

Pathways

• PWY0-1507, biotin biosynthesis from 8-amino-7-oxononanoate I: PWY0-1507
  • 3 reactions found over 3 reactions in the full pathway
• PWY-7380, biotin biosynthesis from 8-amino-7-oxononanoate II: PWY-7380
  • 2 reactions found over 3 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-esiliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-experimental_annotation
    • Tool: pathwaytools
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools

External links

• RHEA:
  • 22060
• LIGAND-RXN:
  • R01078
• UNIPROT:
  • Q9JRW7
  • Q9PLZ3
  • P53557
  • O67104
  • P44987
  • Q58692
  • P0A506
  • Q9Z6L5
  • Q9JUE3
  • P46396
  • Q47862
  • P19206
  • P32451
  • P54967
  • P46715
  • P73538
  • P12996
  • O59778