2.4.1.224-RXN

Reaction 2.4.1.224-RXN

• ec number:
  • EC-2.4.1.224
• direction:
  • LEFT-TO-RIGHT
• common name:
  • N-acetylglucosaminyl-proteoglycan 4-β-glucuronosyltransferase
  • glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 GlcA-GlcNAc-GlcA-Gal-Gal-Xyl-Protein[c] + 1 UDP-N-ACETYL-D-GLUCOSAMINE[c] => 1 UDP[c] + 1 PROTON[c] + 1 GlcNAc-GlcA-GlcNAc-GlcA-Gal-Gal-Xyl-Core[c]
• With common name(s):
  • 1 a [protein]-3-O-(β-D-GlcA-(1→3)-α-D-GlcNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-serine[c] + 1 UDP-N-acetyl-α-D-glucosamine[c] => 1 UDP[c] + 1 H+[c] + 1 a [protein]-3-O-(α-D-GlcNAc-(1→4)-β-D-GlcA-(1→3)-α-D-GlcNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-serine[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: g18599.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g16308.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g7975.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g10339.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g13335.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-saccharina_japonica
• Gene: g10340.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g5428.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-saccharina_japonica
• Gene: g18599.t2
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g14997.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g13334.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-saccharina_japonica
• Gene: g4449.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g13335.t2
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: GO-TERM
  • Source: orthology-saccharina_japonica
• Gene: g10341.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: GO-TERM
• Gene: g13333.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-saccharina_japonica

Pathways

• PWY-6558, heparan sulfate biosynthesis (late stages): PWY-6558
  • 7 reactions found over 13 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-saccharina_japonica
    • Tool: pantograph
• Category: annotation
  • Source: annotation-cladosiphon_okamuranus
    • Tool: pathwaytools

External links

• RHEA:
  • 16214
• LIGAND-RXN:
  • R07334