3-ISOPROPYLMALDEHYDROG-RXN

Reaction 3-ISOPROPYLMALDEHYDROG-RXN

• direction:
  • REVERSIBLE
• common name:
  • 3-isopropylmalate dehydrogenase
• Synonym(s):
  • β-isopropylmalic enzyme
  • threo-Ds-3-isopropylmalate dehydrogenase

Reaction Formula

• With identifiers:
  • 1 2-D-THREO-HYDROXY-3-CARBOXY-ISOCAPROATE[c] + 1 NAD[c] <=> 1 CPD-7100[c] + 1 NADH[c] + 1 PROTON[c]
• With common name(s):
  • 1 (2R,3S)-3-isopropylmalate[c] + 1 NAD+[c] <=> 1 (2S)-2-isopropyl-3-oxosuccinate[c] + 1 NADH[c] + 1 H+[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: g4330.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-ectocarpus_siliculosus
  • Source: orthology-arabidopsis_thaliana
  • Source: orthology-saccharina_japonica

Pathways

• LEUSYN-PWY, L-leucine biosynthesis: LEUSYN-PWY
  • 5 reactions found over 6 reactions in the full pathway
• PWY-6871, 3-methylbutanol biosynthesis (engineered): PWY-6871
  • 5 reactions found over 7 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-saccharina_japonica
    • Tool: pantograph
  • Source: orthology-ectocarpus_siliculosus
    • Tool: pantograph
  • Source: orthology-arabidopsis_thaliana
    • Tool: pantograph
• Category: annotation
  • Source: annotation-cladosiphon_okamuranus
    • Tool: pathwaytools

External links

• UNIPROT:
  • P05644
  • P05645
  • Q01987
  • Q00412
  • P08791
  • P30125
  • Q9PLW0
  • O66607
  • P12010
  • P04173
  • Q5SIY4
  • P24098
  • Q9JU79
  • P43860
  • P41019
  • P54354
  • Q56268
  • P29102
  • P37412
  • P23390
  • P29696
  • P41766
  • Q02143
  • P34733
  • P50180
  • Q12591
  • Q12590
  • Q12592
  • P07139
  • P41926
  • P48012
  • P87256
  • P87257
  • P73960
  • O86504
  • O85837
  • P18869
  • P34738
• RHEA:
  • 10895
• LIGAND-RXN:
  • R04426