RXN-8660

Reaction RXN-8660

• direction:
  • LEFT-TO-RIGHT
• common name:
  • [histone-H3]-lysine-36 demethylase
  • histone demethylase activity (H3-K36 specific)
• Synonym(s):
  • JHDM1A
  • JmjC domain-containing histone demethylase 1A
  • H3-K36-specific demethylase
  • histone-lysine (H3-K36) demethylase
  • histone demethylase
  • protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase

Reaction Formula

• With identifiers:
  • 1 CPD-8900[c] + 1 2-KETOGLUTARATE[c] + 1 OXYGEN-MOLECULE[c] => 1 CPD-8901[c] + 1 SUC[c] + 1 FORMALDEHYDE[c] + 1 CARBON-DIOXIDE[c]
• With common name(s):
  • 1 a [protein] N6,N6-dimethyl-L-lysine[c] + 1 2-oxoglutarate[c] + 1 oxygen[c] => 1 a [protein] N6-methyl-L-lysine[c] + 1 succinate[c] + 1 formaldehyde[c] + 1 CO2[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: g16687.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-saccharina_japonica
• Gene: g7683.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: GO-TERM
  • Source: orthology-saccharina_japonica
• Gene: g8614.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-saccharina_japonica
• Gene: g18712.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: GO-TERM
  • Source: orthology-saccharina_japonica
• Gene: g8811.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-saccharina_japonica
• Gene: g8810.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g12822.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-saccharina_japonica

Reconstruction information

• Category: orthology
  • Source: orthology-saccharina_japonica
    • Tool: pantograph
• Category: annotation
  • Source: annotation-cladosiphon_okamuranus
    • Tool: pathwaytools

External links

• RHEA:
  • 21789

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