RXN490-3641

Reaction RXN490-3641

• ec number:
  • EC-1.14.11.57
• direction:
  • LEFT-TO-RIGHT
• Synonym(s):
  • prolyl hydroxylase
  • prolyl 4-hydroxylase
  • proline,2-oxoglutarate 4-dioxygenase
  • proline hydroxylase
  • protocollagen hydroxylase

Reaction Formula

• With identifiers:
  • 1 PRO[c] + 1 2-KETOGLUTARATE[c] + 1 OXYGEN-MOLECULE[c] => 1 CARBON-DIOXIDE[c] + 1 4-HYDROXY-L-PROLINE[c] + 1 SUC[c]
• With common name(s):
  • 1 L-proline[c] + 1 2-oxoglutarate[c] + 1 oxygen[c] => 1 CO2[c] + 1 trans-4-hydroxy-L-proline[c] + 1 succinate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: g3344.t1
  • Source: orthology-nannochloropsis_salina
  • Source: orthology-arabidopsis_thaliana
  • Source: orthology-saccharina_japonica
• Gene: g3344.t2
  • Source: orthology-nannochloropsis_salina
  • Source: orthology-arabidopsis_thaliana
  • Source: orthology-saccharina_japonica
• Gene: g6279.t1
  • Source: orthology-ectocarpus_siliculosus
  • Source: orthology-saccharina_japonica
• Gene: g12354.t1
  • Source: orthology-ectocarpus_siliculosus
  • Source: orthology-saccharina_japonica

Reconstruction information

• Category: orthology
  • Source: orthology-saccharina_japonica
    • Tool: pantograph
  • Source: orthology-ectocarpus_siliculosus
    • Tool: pantograph
  • Source: orthology-nannochloropsis_salina
    • Tool: pantograph
  • Source: orthology-arabidopsis_thaliana
    • Tool: pantograph

External links

• RHEA:
  • 51509
• LIGAND-RXN:
  • R01252