RXN66-313

Reaction RXN66-313

• ec number:
  • EC-1.1.1.170
• direction:
  • LEFT-TO-RIGHT
• common name:
  • 4α-carboxy-4β-methyl-5α-cholesta-8,24-dien-3β-ol 3-dehydrogenase (decarboxylating)
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 CPD-4577[c] + 1 NAD-P-OR-NOP[c] => 1 NADH-P-OR-NOP[c] + 1 CARBON-DIOXIDE[c] + 1 CPD-4578[c]
• With common name(s):
  • 1 4α-carboxy-4β-methyl-5α-cholesta-8,24-dien-3β-ol[c] + 1 NAD(P)+[c] => 1 NAD(P)H[c] + 1 CO2[c] + 1 3-dehydro-4-methylzymosterol[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: g5433.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
• Gene: g16000.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-ectocarpus_siliculosus
• Gene: g9089.t1
  • Source: annotation-cladosiphon_okamuranus
    • Assignment: EC-NUMBER
  • Source: orthology-saccharina_japonica

Pathways

• PWY66-341, cholesterol biosynthesis I: PWY66-341
  • 12 reactions found over 22 reactions in the full pathway
• PWY66-4, cholesterol biosynthesis III (via desmosterol): PWY66-4
  • 12 reactions found over 22 reactions in the full pathway
• PWY-6074, zymosterol biosynthesis: PWY-6074
  • 6 reactions found over 12 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-saccharina_japonica
    • Tool: pantograph
  • Source: orthology-ectocarpus_siliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-cladosiphon_okamuranus
    • Tool: pathwaytools

External links

• RHEA:
  • 33448
• LIGAND-RXN:
  • R07494