DIHYDROFOLATEREDUCT-RXN

Reaction DIHYDROFOLATEREDUCT-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • Tetrahydrofolate dehydrogenase/cyclohydrolase
  • Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  • dihydrofolate reductase
  • Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
• ec number:
  • EC-1.5.1.3
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 NADPH[c] + 1 PROTON[c] + 1 DIHYDROFOLATE-GLU-N[c] => 1 NADP[c] + 1 THF-GLU-N[c]
• With common name(s):
  • 1 NADPH[c] + 1 H+[c] + 1 a 7,8-dihydrofolate[c] => 1 NADP+[c] + 1 a tetrahydrofolate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Ec-15_001370
  • Source: annotation-esiliculosus_genome
    • Assignment: AUTOMATED-NAME-MATCH
• Gene: Ec-07_007470
  • Source: annotation-esiliculosus_genome
    • Assignment: AUTOMATED-NAME-MATCH
• Gene: Ec-27_004630
  • Source: annotation-esiliculosus_genome
    • Assignment: GO-TERM
• Gene: Ec-14_004070
  • Source: annotation-esiliculosus_genome
    • Assignment: AUTOMATED-NAME-MATCH

Pathways

• 1CMET2-PWY, N10-formyl-tetrahydrofolate biosynthesis: 1CMET2-PWY
  • 9 reactions found over 9 reactions in the full pathway
• PWY-6614, tetrahydrofolate biosynthesis: PWY-6614
  • 3 reactions found over 3 reactions in the full pathway
• PWY-3841, folate transformations II: PWY-3841
  • 10 reactions found over 11 reactions in the full pathway

Reconstruction information

• Category: manual
  • Source: manual-erythro
  • Source: manual-sphingo361
  • Source: manual-sphingo391
  • Source: manual-roseov420
  • Source: manual-rhizobi
  • Source: manual-hoflea
  • Source: manual-imperaili
  • Source: manual-roseov134
  • Source: manual-marino
  • Source: manual-bosea
• Category: annotation
  • Source: annotation-esiliculosus_genome
    • Tool: pathwaytools

External links

• LIGAND-RXN:
  • R00939