HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN

Reaction HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • Hydroxymethylglutaryl-CoA lyase
• ec number:
  • EC-4.1.3.4
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 3-HYDROXY-3-METHYL-GLUTARYL-COA[c] => 1 3-KETOBUTYRATE[c] + 1 ACETYL-COA[c]
• With common name(s):
  • 1 (S)-3-hydroxy-3-methylglutaryl-CoA[c] => 1 acetoacetate[c] + 1 acetyl-CoA[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Ec-26_006120
  • Source: annotation-esiliculosus_genome
    • Assignment: EC-NUMBER
  • Source: orthology-aragem

Pathways

• PWY66-367, ketogenesis: PWY66-367
  • 5 reactions found over 5 reactions in the full pathway
• LEU-DEG2-PWY, L-leucine degradation I: LEU-DEG2-PWY
  • 6 reactions found over 6 reactions in the full pathway
• PWY-5074, mevalonate degradation: PWY-5074
  • 1 reactions found over 2 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-aragem
    • Tool: pantograph
• Category: manual
  • Source: manual-erythro
  • Source: manual-sphingo361
  • Source: manual-sphingo391
  • Source: manual-roseov420
  • Source: manual-rhizobi
  • Source: manual-hoflea
  • Source: manual-imperaili
  • Source: manual-roseov134
  • Source: manual-marino
  • Source: manual-bosea
• Category: annotation
  • Source: annotation-esiliculosus_genome
    • Tool: pathwaytools

External links

• RHEA:
  • 24404
• LIGAND-RXN:
  • R01360
• UNIPROT:
  • P35914
  • P35915
  • Q8L7K2