RXN-8991

Reaction RXN-8991

• direction:
  • REVERSIBLE
• common name:
  • 3-isopropylmalate dehydratase
  • Aconitase/3-isopropylmalate dehydratase, swivel
• Synonym(s):
  • (2R,3S)-3-isopropylmalate hydro-lyase
  • β-isopropylmalate dehydratase
  • α-isopropylmalate isomerase
  • 3-isopropylmalate hydro-lyase

Reaction Formula

• With identifiers:
  • 1 2-D-THREO-HYDROXY-3-CARBOXY-ISOCAPROATE[c] <=> 1 WATER[c] + 1 CPD-9451[c]
• With common name(s):
  • 1 (2R,3S)-3-isopropylmalate[c] <=> 1 H2O[c] + 1 2-isopropylmaleate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Ec-sdr_f_000030
  • Source: orthology-aragem
• Gene: Ec-13_001950
  • Source: orthology-aragem
• Gene: Ec-12_000170
  • Source: annotation-esiliculosus_genome
    • Assignment: EC-NUMBER
  • Source: orthology-aragem

Pathways

• LEUSYN-PWY, L-leucine biosynthesis: LEUSYN-PWY
  • 6 reactions found over 6 reactions in the full pathway
• PWY-6871, 3-methylbutanol biosynthesis (engineered): PWY-6871
  • 6 reactions found over 7 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-aragem
    • Tool: pantograph
• Category: manual
  • Source: manual-erythro
  • Source: manual-sphingo361
  • Source: manual-sphingo391
  • Source: manual-hoflea
  • Source: manual-rhizobi
  • Source: manual-roseov420
  • Source: manual-imperaili
  • Source: manual-roseov134
  • Source: manual-marino
  • Source: manual-bosea
• Category: annotation
  • Source: annotation-esiliculosus_genome
    • Tool: pathwaytools

External links

• RHEA:
  • 10676
• LIGAND-RXN:
  • R04001