View source for Ec-18 003900

[[Category:Reaction]]
== Reaction [http://metacyc.org/META/NEW-IMAGE?object=DIHYDROFOLATEREDUCT-RXN DIHYDROFOLATEREDUCT-RXN] ==
* direction:
** LEFT-TO-RIGHT
* common name:
** Tetrahydrofolate dehydrogenase/cyclohydrolase
** Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
** dihydrofolate reductase
** Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
* ec number:
** [http://enzyme.expasy.org/EC/1.5.1.3 EC-1.5.1.3]
* Synonym(s):

== Reaction Formula ==
* With identifiers:
** 1 [[NADPH]][c] '''+''' 1 [[PROTON]][c] '''+''' 1 [[DIHYDROFOLATE-GLU-N]][c] '''=>''' 1 [[THF-GLU-N]][c] '''+''' 1 [[NADP]][c]
* With common name(s):
** 1 NADPH[c] '''+''' 1 H+[c] '''+''' 1 a 7,8-dihydrofolate[c] '''=>''' 1 a tetrahydrofolate[c] '''+''' 1 NADP+[c]

== Genes associated with this reaction  ==
Genes have been associated with this reaction based on different elements listed below.
* Gene: [[Ec-15_001370]]
** Source: [[annotation-esiliculosus_genome]]
*** Assignment: AUTOMATED-NAME-MATCH
* Gene: [[Ec-07_007470]]
** Source: [[annotation-esiliculosus_genome]]
*** Assignment: AUTOMATED-NAME-MATCH
* Gene: [[Ec-27_004630]]
** Source: [[annotation-esiliculosus_genome]]
*** Assignment: GO-TERM
* Gene: [[Ec-14_004070]]
** Source: [[annotation-esiliculosus_genome]]
*** Assignment: AUTOMATED-NAME-MATCH
== Pathways  ==
* [[1CMET2-PWY]], N10-formyl-tetrahydrofolate biosynthesis: [http://metacyc.org/META/NEW-IMAGE?object=1CMET2-PWY 1CMET2-PWY]
** '''9''' reactions found over '''9''' reactions in the full pathway
* [[PWY-6614]], tetrahydrofolate biosynthesis: [http://metacyc.org/META/NEW-IMAGE?object=PWY-6614 PWY-6614]
** '''3''' reactions found over '''3''' reactions in the full pathway
* [[PWY-3841]], folate transformations II: [http://metacyc.org/META/NEW-IMAGE?object=PWY-3841 PWY-3841]
** '''10''' reactions found over '''11''' reactions in the full pathway
== Reconstruction information  ==
* Category: [[annotation]]
** Source: [[annotation-esiliculosus_genome]]
*** Tool: [[pathwaytools]]
== External links  ==
* LIGAND-RXN:
** [http://www.genome.jp/dbget-bin/www_bget?R00939 R00939]
{{#set: direction=LEFT-TO-RIGHT}}
{{#set: common name=Tetrahydrofolate dehydrogenase/cyclohydrolase}}
{{#set: common name=Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain}}
{{#set: common name=dihydrofolate reductase}}
{{#set: common name=Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain}}
{{#set: ec number=EC-1.5.1.3}}
{{#set: gene associated=Ec-15_001370|Ec-07_007470|Ec-27_004630|Ec-14_004070}}
{{#set: in pathway=1CMET2-PWY|PWY-6614|PWY-3841}}
{{#set: reconstruction category=annotation}}
{{#set: reconstruction source=annotation-esiliculosus_genome}}
{{#set: reconstruction tool=pathwaytools}}