View source for 3-ISOPROPYLMALDEHYDROG-RXN

[[Category:Reaction]]
== Reaction [http://metacyc.org/META/NEW-IMAGE?object=3-ISOPROPYLMALDEHYDROG-RXN 3-ISOPROPYLMALDEHYDROG-RXN] ==
* direction:
** REVERSIBLE
* common name:
** 3-isopropylmalate dehydrogenase
* Synonym(s):
** &beta;-isopropylmalic enzyme
** threo-Ds-3-isopropylmalate dehydrogenase

== Reaction Formula ==
* With identifiers:
** 1 [[2-D-THREO-HYDROXY-3-CARBOXY-ISOCAPROATE]][c] '''+''' 1 [[NAD]][c] '''<=>''' 1 [[CPD-7100]][c] '''+''' 1 [[PROTON]][c] '''+''' 1 [[NADH]][c]
* With common name(s):
** 1 (2R,3S)-3-isopropylmalate[c] '''+''' 1 NAD+[c] '''<=>''' 1 (2S)-2-isopropyl-3-oxosuccinate[c] '''+''' 1 H+[c] '''+''' 1 NADH[c]

== Genes associated with this reaction  ==
Genes have been associated with this reaction based on different elements listed below.
* Gene: [[Ec-16_002120]]
** Source: [[annotation-esiliculosus_genome]]
*** Assignment: EC-NUMBER
** Source: [[orthology-aragem]]
== Pathways  ==
* [[LEUSYN-PWY]], L-leucine biosynthesis: [http://metacyc.org/META/NEW-IMAGE?object=LEUSYN-PWY LEUSYN-PWY]
** '''6''' reactions found over '''6''' reactions in the full pathway
* [[PWY-6871]], 3-methylbutanol biosynthesis (engineered): [http://metacyc.org/META/NEW-IMAGE?object=PWY-6871 PWY-6871]
** '''5''' reactions found over '''7''' reactions in the full pathway
== Reconstruction information  ==
* Category: [[orthology]]
** Source: [[orthology-aragem]]
*** Tool: [[pantograph]]
* Category: [[annotation]]
** Source: [[annotation-esiliculosus_genome]]
*** Tool: [[pathwaytools]]
== External links  ==
* RHEA:
** [http://www.ebi.ac.uk/rhea/reaction.xhtml?id=10892 10892]
* LIGAND-RXN:
** [http://www.genome.jp/dbget-bin/www_bget?R04426 R04426]
* UNIPROT:
** [http://www.uniprot.org/uniprot/P05644 P05644]
** [http://www.uniprot.org/uniprot/P05645 P05645]
** [http://www.uniprot.org/uniprot/Q01987 Q01987]
** [http://www.uniprot.org/uniprot/Q00412 Q00412]
** [http://www.uniprot.org/uniprot/P08791 P08791]
** [http://www.uniprot.org/uniprot/P30125 P30125]
** [http://www.uniprot.org/uniprot/Q9PLW0 Q9PLW0]
** [http://www.uniprot.org/uniprot/O66607 O66607]
** [http://www.uniprot.org/uniprot/P12010 P12010]
** [http://www.uniprot.org/uniprot/P04173 P04173]
** [http://www.uniprot.org/uniprot/Q5SIY4 Q5SIY4]
** [http://www.uniprot.org/uniprot/P24098 P24098]
** [http://www.uniprot.org/uniprot/Q9JU79 Q9JU79]
** [http://www.uniprot.org/uniprot/P43860 P43860]
** [http://www.uniprot.org/uniprot/P41019 P41019]
** [http://www.uniprot.org/uniprot/P54354 P54354]
** [http://www.uniprot.org/uniprot/Q56268 Q56268]
** [http://www.uniprot.org/uniprot/P29102 P29102]
** [http://www.uniprot.org/uniprot/P37412 P37412]
** [http://www.uniprot.org/uniprot/P23390 P23390]
** [http://www.uniprot.org/uniprot/P29696 P29696]
** [http://www.uniprot.org/uniprot/P41766 P41766]
** [http://www.uniprot.org/uniprot/Q02143 Q02143]
** [http://www.uniprot.org/uniprot/P34733 P34733]
** [http://www.uniprot.org/uniprot/P50180 P50180]
** [http://www.uniprot.org/uniprot/Q12591 Q12591]
** [http://www.uniprot.org/uniprot/Q12590 Q12590]
** [http://www.uniprot.org/uniprot/Q12592 Q12592]
** [http://www.uniprot.org/uniprot/P07139 P07139]
** [http://www.uniprot.org/uniprot/P41926 P41926]
** [http://www.uniprot.org/uniprot/P48012 P48012]
** [http://www.uniprot.org/uniprot/P87256 P87256]
** [http://www.uniprot.org/uniprot/P87257 P87257]
** [http://www.uniprot.org/uniprot/P73960 P73960]
** [http://www.uniprot.org/uniprot/O86504 O86504]
** [http://www.uniprot.org/uniprot/O85837 O85837]
** [http://www.uniprot.org/uniprot/P18869 P18869]
** [http://www.uniprot.org/uniprot/P34738 P34738]
{{#set: direction=REVERSIBLE}}
{{#set: common name=3-isopropylmalate dehydrogenase}}
{{#set: common name=&beta;-isopropylmalic enzyme|threo-Ds-3-isopropylmalate dehydrogenase}}
{{#set: gene associated=Ec-16_002120}}
{{#set: in pathway=LEUSYN-PWY|PWY-6871}}
{{#set: reconstruction category=orthology|annotation}}
{{#set: reconstruction source=annotation-esiliculosus_genome|orthology-aragem}}
{{#set: reconstruction tool=pantograph|pathwaytools}}