Difference between revisions of "HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN"

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(Created page with "Category:Metabolite == Metabolite [http://metacyc.org/META/NEW-IMAGE?object=CPD-15435 CPD-15435] == * smiles: ** CC(O)C(C([O-])=O)NC(=O)OP(OCC3(C(C(C(N2(C1(=C(C(=NC=N1)N)N...")
(Created page with "Category:Reaction == Reaction [http://metacyc.org/META/NEW-IMAGE?object=HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN] == * direction: ** LEFT-TO...")
 
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[[Category:Metabolite]]
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[[Category:Reaction]]
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== Metabolite [http://metacyc.org/META/NEW-IMAGE?object=CPD-15435 CPD-15435] ==
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== Reaction [http://metacyc.org/META/NEW-IMAGE?object=HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN] ==
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* smiles:
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* direction:
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** CC(O)C(C([O-])=O)NC(=O)OP(OCC3(C(C(C(N2(C1(=C(C(=NC=N1)N)N=C2)))O3)O)O))([O-])=O
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** LEFT-TO-RIGHT
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* inchi key:
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** InChIKey=GHLUPQUHEIJRCU-DWVDDHQFSA-L
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* common name:
 
* common name:
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** L-threonylcarbamoyladenylate
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** Hydroxymethylglutaryl-CoA lyase
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* molecular weight:
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* ec number:
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** 490.322   
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** [http://enzyme.expasy.org/EC/4.1.3.4 EC-4.1.3.4]
 
* Synonym(s):
 
* Synonym(s):
  
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== Reaction(s) known to consume the compound ==
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== Reaction Formula ==
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* [[RXN-14570]]
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* With identifiers:
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== Reaction(s) known to produce the compound ==
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** 1 [[3-HYDROXY-3-METHYL-GLUTARYL-COA]][c] '''=>''' 1 [[ACETYL-COA]][c] '''+''' 1 [[3-KETOBUTYRATE]][c]
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== Reaction(s) of unknown directionality ==
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* With common name(s):
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* [[RXN-14569]]
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** 1 (S)-3-hydroxy-3-methylglutaryl-CoA[c] '''=>''' 1 acetyl-CoA[c] '''+''' 1 acetoacetate[c]
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== Genes associated with this reaction  ==
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Genes have been associated with this reaction based on different elements listed below.
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* Gene: [[Ec-26_006120]]
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** Source: [[annotation-esiliculosus_genome]]
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*** Assignment: EC-NUMBER
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** Source: [[orthology-aragem]]
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== Pathways  ==
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* [[PWY66-367]], ketogenesis: [http://metacyc.org/META/NEW-IMAGE?object=PWY66-367 PWY66-367]
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** '''3''' reactions found over '''5''' reactions in the full pathway
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* [[LEU-DEG2-PWY]], L-leucine degradation I: [http://metacyc.org/META/NEW-IMAGE?object=LEU-DEG2-PWY LEU-DEG2-PWY]
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** '''6''' reactions found over '''6''' reactions in the full pathway
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* [[PWY-5074]], mevalonate degradation: [http://metacyc.org/META/NEW-IMAGE?object=PWY-5074 PWY-5074]
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** '''1''' reactions found over '''2''' reactions in the full pathway
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== Reconstruction information  ==
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* Category: [[orthology]]
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** Source: [[orthology-aragem]]
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*** Tool: [[pantograph]]
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* Category: [[annotation]]
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** Source: [[annotation-esiliculosus_genome]]
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*** Tool: [[pathwaytools]]
 
== External links  ==
 
== External links  ==
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* PUBCHEM:
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* RHEA:
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** [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=71464565 71464565]
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** [http://www.ebi.ac.uk/rhea/reaction.xhtml?id=24404 24404]
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* CHEBI:
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* LIGAND-RXN:
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** [http://www.ebi.ac.uk/chebi/searchId.do?chebiId=73682 73682]
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** [http://www.genome.jp/dbget-bin/www_bget?R01360 R01360]
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{{#set: smiles=CC(O)C(C([O-])=O)NC(=O)OP(OCC3(C(C(C(N2(C1(=C(C(=NC=N1)N)N=C2)))O3)O)O))([O-])=O}}
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* UNIPROT:
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{{#set: inchi key=InChIKey=GHLUPQUHEIJRCU-DWVDDHQFSA-L}}
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** [http://www.uniprot.org/uniprot/P35914 P35914]
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{{#set: common name=L-threonylcarbamoyladenylate}}
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** [http://www.uniprot.org/uniprot/P35915 P35915]
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{{#set: molecular weight=490.322    }}
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** [http://www.uniprot.org/uniprot/Q8L7K2 Q8L7K2]
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{{#set: consumed by=RXN-14570}}
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{{#set: direction=LEFT-TO-RIGHT}}
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{{#set: reversible reaction associated=RXN-14569}}
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{{#set: common name=Hydroxymethylglutaryl-CoA lyase}}
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{{#set: ec number=EC-4.1.3.4}}
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{{#set: gene associated=Ec-26_006120}}
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{{#set: in pathway=PWY66-367|LEU-DEG2-PWY|PWY-5074}}
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{{#set: reconstruction category=orthology|annotation}}
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{{#set: reconstruction source=annotation-esiliculosus_genome|orthology-aragem}}
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{{#set: reconstruction tool=pantograph|pathwaytools}}

Latest revision as of 20:43, 21 March 2018

Reaction HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN

  • direction:
    • LEFT-TO-RIGHT
  • common name:
    • Hydroxymethylglutaryl-CoA lyase
  • ec number:
  • Synonym(s):

Reaction Formula

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

Pathways

  • PWY66-367, ketogenesis: PWY66-367
    • 3 reactions found over 5 reactions in the full pathway
  • LEU-DEG2-PWY, L-leucine degradation I: LEU-DEG2-PWY
    • 6 reactions found over 6 reactions in the full pathway
  • PWY-5074, mevalonate degradation: PWY-5074
    • 1 reactions found over 2 reactions in the full pathway

Reconstruction information

External links





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