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| [[Category:Reaction]] | | [[Category:Reaction]] |
− | == Reaction [http://metacyc.org/META/NEW-IMAGE?object=ACETYL-COA-ACETYLTRANSFER-RXN ACETYL-COA-ACETYLTRANSFER-RXN] == | + | == Reaction [http://metacyc.org/META/NEW-IMAGE?object=RXN0-5180 RXN0-5180] == |
| * direction: | | * direction: |
| ** REVERSIBLE | | ** REVERSIBLE |
− | * common name:
| |
− | ** Thiolase, C-terminal
| |
− | ** Acetyl-CoA acetyltransferase
| |
| * ec number: | | * ec number: |
− | ** [http://enzyme.expasy.org/EC/2.3.1.9 EC-2.3.1.9] | + | ** [http://enzyme.expasy.org/EC/2.5.1 EC-2.5.1] |
| * Synonym(s): | | * Synonym(s): |
| | | |
| == Reaction Formula == | | == Reaction Formula == |
| * With identifiers: | | * With identifiers: |
− | ** 2 [[ACETYL-COA]][c] '''<=>''' 1 [[CO-A]][c] '''+''' 1 [[ACETOACETYL-COA]][c] | + | ** 1 [[FARNESYL-PP]][c] '''+''' 1 [[DELTA3-ISOPENTENYL-PP]][c] '''<=>''' 1 [[CPD0-1028]][c] '''+''' 1 [[PPI]][c] |
| * With common name(s): | | * With common name(s): |
− | ** 2 acetyl-CoA[c] '''<=>''' 1 coenzyme A[c] '''+''' 1 acetoacetyl-CoA[c] | + | ** 1 (2E,6E)-farnesyl diphosphate[c] '''+''' 1 isopentenyl diphosphate[c] '''<=>''' 1 2-cis,6-trans,10-trans-geranylgeranyl diphosphate[c] '''+''' 1 diphosphate[c] |
| | | |
| == Genes associated with this reaction == | | == Genes associated with this reaction == |
| Genes have been associated with this reaction based on different elements listed below. | | Genes have been associated with this reaction based on different elements listed below. |
− | * [[Ec-26_003940]] | + | * Gene: [[Ec-27_002140]] |
− | ** [[pantograph]]-[[aragem]] | + | ** Source: [[orthology-aragem]] |
− | * [[Ec-24_000870]] | + | * Gene: [[Ec-05_002690]] |
− | ** ESILICULOSUS_GENOME | + | ** Source: [[orthology-aragem]] |
− | ***EC-NUMBER
| + | * Gene: [[Ec-17_003520]] |
− | * [[Ec-22_002850]] | + | ** Source: [[orthology-aragem]] |
− | ** ESILICULOSUS_GENOME | + | * Gene: [[Ec-18_000990]] |
− | ***EC-NUMBER | + | ** Source: [[orthology-aragem]] |
− | ** [[pantograph]]-[[aragem]] | + | * Gene: [[Ec-08_002270]] |
− | ** [[pantograph]]-[[aragem]] | + | ** Source: [[orthology-aragem]] |
− | ** [[pantograph]]-[[aragem]] | + | * Gene: [[Ec-24_003910]] |
− | ** [[pantograph]]-[[aragem]] | + | ** Source: [[orthology-aragem]] |
| == Pathways == | | == Pathways == |
− | * [[P162-PWY]], L-glutamate degradation V (via hydroxyglutarate): [http://metacyc.org/META/NEW-IMAGE?object=P162-PWY P162-PWY]
| |
− | ** '''4''' reactions found over '''11''' reactions in the full pathway
| |
− | * [[PWY-5177]], glutaryl-CoA degradation: [http://metacyc.org/META/NEW-IMAGE?object=PWY-5177 PWY-5177]
| |
− | ** '''3''' reactions found over '''5''' reactions in the full pathway
| |
− | * [[PWY-6583]], pyruvate fermentation to butanol I: [http://metacyc.org/META/NEW-IMAGE?object=PWY-6583 PWY-6583]
| |
− | ** '''4''' reactions found over '''8''' reactions in the full pathway
| |
− | * [[P163-PWY]], L-lysine fermentation to acetate and butanoate: [http://metacyc.org/META/NEW-IMAGE?object=P163-PWY P163-PWY]
| |
− | ** '''1''' reactions found over '''10''' reactions in the full pathway
| |
− | * [[PWY-6883]], pyruvate fermentation to butanol II (engineered): [http://metacyc.org/META/NEW-IMAGE?object=PWY-6883 PWY-6883]
| |
− | ** '''3''' reactions found over '''6''' reactions in the full pathway
| |
− | * [[PWY-5676]], acetyl-CoA fermentation to butanoate II: [http://metacyc.org/META/NEW-IMAGE?object=PWY-5676 PWY-5676]
| |
− | ** '''1''' reactions found over '''7''' reactions in the full pathway
| |
− | * [[PWY-7778]], 2-methylpropene degradation: [http://metacyc.org/META/NEW-IMAGE?object=PWY-7778 PWY-7778]
| |
− | ** '''2''' reactions found over '''8''' reactions in the full pathway
| |
− | * [[PWY-7779]], methyl tert-butyl ether degradation: [http://metacyc.org/META/NEW-IMAGE?object=PWY-7779 PWY-7779]
| |
− | ** '''2''' reactions found over '''10''' reactions in the full pathway
| |
− | * [[PWY-6588]], pyruvate fermentation to acetone: [http://metacyc.org/META/NEW-IMAGE?object=PWY-6588 PWY-6588]
| |
− | ** '''2''' reactions found over '''5''' reactions in the full pathway
| |
− | * [[PWY1-3]], polyhydroxybutanoate biosynthesis: [http://metacyc.org/META/NEW-IMAGE?object=PWY1-3 PWY1-3]
| |
− | ** '''1''' reactions found over '''3''' reactions in the full pathway
| |
− | * [[PWY-5789]], 3-hydroxypropanoate/4-hydroxybutanate cycle: [http://metacyc.org/META/NEW-IMAGE?object=PWY-5789 PWY-5789]
| |
− | ** '''6''' reactions found over '''16''' reactions in the full pathway
| |
− | * [[PWY-6876]], isopropanol biosynthesis (engineered): [http://metacyc.org/META/NEW-IMAGE?object=PWY-6876 PWY-6876]
| |
− | ** '''2''' reactions found over '''5''' reactions in the full pathway
| |
− | * [[CENTFERM-PWY]], pyruvate fermentation to butanoate: [http://metacyc.org/META/NEW-IMAGE?object=CENTFERM-PWY CENTFERM-PWY]
| |
− | ** '''4''' reactions found over '''7''' reactions in the full pathway
| |
− | * [[PWY-7391]], isoprene biosynthesis II (engineered): [http://metacyc.org/META/NEW-IMAGE?object=PWY-7391 PWY-7391]
| |
− | ** '''7''' reactions found over '''8''' reactions in the full pathway
| |
− | * [[PWY-5741]], ethylmalonyl-CoA pathway: [http://metacyc.org/META/NEW-IMAGE?object=PWY-5741 PWY-5741]
| |
− | ** '''1''' reactions found over '''11''' reactions in the full pathway
| |
− | * [[PWY-6174]], mevalonate pathway II (archaea): [http://metacyc.org/META/NEW-IMAGE?object=PWY-6174 PWY-6174]
| |
− | ** '''5''' reactions found over '''7''' reactions in the full pathway
| |
− | * [[ACETOACETATE-DEG-PWY]], acetoacetate degradation (to acetyl CoA): [http://metacyc.org/META/NEW-IMAGE?object=ACETOACETATE-DEG-PWY ACETOACETATE-DEG-PWY]
| |
− | ** '''1''' reactions found over '''2''' reactions in the full pathway
| |
− | * [[PWY66-367]], ketogenesis: [http://metacyc.org/META/NEW-IMAGE?object=PWY66-367 PWY66-367]
| |
− | ** '''3''' reactions found over '''5''' reactions in the full pathway
| |
− | * [[PWY-7216]], (R)- and (S)-3-hydroxybutanoate biosynthesis (engineered): [http://metacyc.org/META/NEW-IMAGE?object=PWY-7216 PWY-7216]
| |
− | ** '''2''' reactions found over '''5''' reactions in the full pathway
| |
− | * [[PWY-922]], mevalonate pathway I: [http://metacyc.org/META/NEW-IMAGE?object=PWY-922 PWY-922]
| |
− | ** '''7''' reactions found over '''7''' reactions in the full pathway
| |
− | * [[PWY66-368]], ketolysis: [http://metacyc.org/META/NEW-IMAGE?object=PWY66-368 PWY66-368]
| |
− | ** '''1''' reactions found over '''3''' reactions in the full pathway
| |
− | * [[PWY-7401]], crotonate fermentation (to acetate and cyclohexane carboxylate): [http://metacyc.org/META/NEW-IMAGE?object=PWY-7401 PWY-7401]
| |
− | ** '''4''' reactions found over '''16''' reactions in the full pathway
| |
− | * [[PWY-6863]], pyruvate fermentation to hexanol (engineered): [http://metacyc.org/META/NEW-IMAGE?object=PWY-6863 PWY-6863]
| |
− | ** '''7''' reactions found over '''11''' reactions in the full pathway
| |
− | * [[PWY-7524]], mevalonate pathway III (archaea): [http://metacyc.org/META/NEW-IMAGE?object=PWY-7524 PWY-7524]
| |
− | ** '''4''' reactions found over '''8''' reactions in the full pathway
| |
| == Reconstruction information == | | == Reconstruction information == |
| * Category: [[orthology]] | | * Category: [[orthology]] |
| ** Source: [[orthology-aragem]] | | ** Source: [[orthology-aragem]] |
| *** Tool: [[pantograph]] | | *** Tool: [[pantograph]] |
− | * Category: [[annotation]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Tool: [[pathwaytools]]
| |
| == External links == | | == External links == |
| * RHEA: | | * RHEA: |
− | ** [http://www.ebi.ac.uk/rhea/reaction.xhtml?id=21036 21036] | + | ** [http://www.ebi.ac.uk/rhea/reaction.xhtml?id=31282 31282] |
| * LIGAND-RXN: | | * LIGAND-RXN: |
− | ** [http://www.genome.jp/dbget-bin/www_bget?R00238 R00238] | + | ** [http://www.genome.jp/dbget-bin/www_bget?R05555 R05555] |
− | * UNIPROT:
| + | |
− | ** [http://www.uniprot.org/uniprot/Q8CAY6 Q8CAY6]
| + | |
− | ** [http://www.uniprot.org/uniprot/P41338 P41338]
| + | |
− | ** [http://www.uniprot.org/uniprot/P45362 P45362]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q9BWD1 Q9BWD1]
| + | |
− | ** [http://www.uniprot.org/uniprot/P45359 P45359]
| + | |
− | ** [http://www.uniprot.org/uniprot/P24752 P24752]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q12598 Q12598]
| + | |
− | ** [http://www.uniprot.org/uniprot/P45369 P45369]
| + | |
− | ** [http://www.uniprot.org/uniprot/P46707 P46707]
| + | |
− | ** [http://www.uniprot.org/uniprot/P73825 P73825]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q43637 Q43637]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q9UQW6 Q9UQW6]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q9Z3Y4 Q9Z3Y4]
| + | |
− | ** [http://www.uniprot.org/uniprot/P77852 P77852]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q9XD81 Q9XD81]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q9ZGI9 Q9ZGI9]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q9L8E0 Q9L8E0]
| + | |
− | ** [http://www.uniprot.org/uniprot/P14611 P14611]
| + | |
− | ** [http://www.uniprot.org/uniprot/P07097 P07097]
| + | |
− | ** [http://www.uniprot.org/uniprot/P17764 P17764]
| + | |
| {{#set: direction=REVERSIBLE}} | | {{#set: direction=REVERSIBLE}} |
− | {{#set: common name=Thiolase, C-terminal}}
| + | {{#set: ec number=EC-2.5.1}} |
− | {{#set: common name=Acetyl-CoA acetyltransferase}}
| + | {{#set: gene associated=Ec-27_002140|Ec-05_002690|Ec-17_003520|Ec-18_000990|Ec-08_002270|Ec-24_003910}} |
− | {{#set: ec number=EC-2.3.1.9}} | + | {{#set: in pathway=}} |
− | {{#set: gene associated=Ec-26_003940|Ec-24_000870|Ec-22_002850}} | + | {{#set: reconstruction category=orthology}} |
− | {{#set: in pathway=P162-PWY|PWY-5177|PWY-6583|P163-PWY|PWY-6883|PWY-5676|PWY-7778|PWY-7779|PWY-6588|PWY1-3|PWY-5789|PWY-6876|CENTFERM-PWY|PWY-7391|PWY-5741|PWY-6174|ACETOACETATE-DEG-PWY|PWY66-367|PWY-7216|PWY-922|PWY66-368|PWY-7401|PWY-6863|PWY-7524}} | + | {{#set: reconstruction source=orthology-aragem}} |
− | {{#set: reconstruction category=orthology|annotation}} | + | {{#set: reconstruction tool=pantograph}} |
− | {{#set: reconstruction source=annotation-esiliculosus_genome|orthology-aragem}} | + | |
− | {{#set: reconstruction tool=pantograph|pathwaytools}} | + | |
Genes have been associated with this reaction based on different elements listed below.