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| [[Category:Reaction]] | | [[Category:Reaction]] |
− | == Reaction [http://metacyc.org/META/NEW-IMAGE?object=UBIQUITIN--PROTEIN-LIGASE-RXN UBIQUITIN--PROTEIN-LIGASE-RXN] == | + | == Reaction [http://metacyc.org/META/NEW-IMAGE?object=RXN-7911 RXN-7911] == |
| * direction: | | * direction: |
− | ** LEFT-TO-RIGHT | + | ** REVERSIBLE |
| * common name: | | * common name: |
− | ** ubiquitin-protein transferase | + | ** NAD(P)-binding domain |
− | ** Ubiquitin-activating enzyme e1, C-terminal
| + | |
− | ** putative ubiquitin activating enzyme
| + | |
− | ** Ubiquitin activating enzyme (E1) subunit UBA3
| + | |
| * ec number: | | * ec number: |
− | ** [http://enzyme.expasy.org/EC/6.2.1.45 EC-6.2.1.45] | + | ** [http://enzyme.expasy.org/EC/1.3.1.34 EC-1.3.1.34] |
| * Synonym(s): | | * Synonym(s): |
| | | |
| == Reaction Formula == | | == Reaction Formula == |
| * With identifiers: | | * With identifiers: |
− | ** 1 [[Ubiquitin-C-Terminal-Glycine]][c] '''+''' 1 [[ATP]][c] '''+''' 1 [[Ubiquitin-activating-protein-E1-L-cys]][c] '''=>''' 1 [[AMP]][c] '''+''' 1 [[PPI]][c] '''+''' 1 [[S-ubiquitinyl-UAP-E1-L-cysteine]][c] | + | ** 1 [[NADP]][c] '''+''' 1 [[TRANS-D2-ENOYL-COA]][c] '''<=>''' 1 [[NADPH]][c] '''+''' 1 [[PROTON]][c] '''+''' 1 [[TETRADEHYDROACYL-COA]][c] |
| * With common name(s): | | * With common name(s): |
− | ** 1 a [ubiquitin] C-terminal glycine[c] '''+''' 1 ATP[c] '''+''' 1 an [E1 ubiquitin-activating enzyme]-L-cysteine[c] '''=>''' 1 AMP[c] '''+''' 1 diphosphate[c] '''+''' 1 an S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine[c] | + | ** 1 NADP+[c] '''+''' 1 a trans-2-enoyl-CoA[c] '''<=>''' 1 NADPH[c] '''+''' 1 H+[c] '''+''' 1 a trans-2,trans-4-dienoyl-CoA[c] |
| | | |
| == Genes associated with this reaction == | | == Genes associated with this reaction == |
| Genes have been associated with this reaction based on different elements listed below. | | Genes have been associated with this reaction based on different elements listed below. |
− | * Gene: [[Ec-09_004750]] | + | * Gene: [[Ec-16_003950]] |
| ** Source: [[annotation-esiliculosus_genome]] | | ** Source: [[annotation-esiliculosus_genome]] |
| *** Assignment: EC-NUMBER | | *** Assignment: EC-NUMBER |
− | * Gene: [[Ec-13_002660]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-01_007490]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-26_001140]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-22_002200]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-01_008900]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-01_009550]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-06_002450]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-25_000510]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-25_002490]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-18_001830]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-01_001660]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-14_006720]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-25_000920]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-14_003730]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-00_007160]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-25_000910]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-09_000720]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-14_001990]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-25_002630]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-27_002840]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-01_010570]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-16_001360]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: GO-TERM
| |
− | * Gene: [[Ec-24_003940]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: AUTOMATED-NAME-MATCH
| |
− | * Gene: [[Ec-12_000320]]
| |
− | ** Source: [[annotation-esiliculosus_genome]]
| |
− | *** Assignment: AUTOMATED-NAME-MATCH
| |
| == Pathways == | | == Pathways == |
− | * [[PWY-7511]], protein ubiquitylation: [http://metacyc.org/META/NEW-IMAGE?object=PWY-7511 PWY-7511]
| |
− | ** '''9''' reactions found over '''9''' reactions in the full pathway
| |
| == Reconstruction information == | | == Reconstruction information == |
| * Category: [[annotation]] | | * Category: [[annotation]] |
Line 104: |
Line 27: |
| == External links == | | == External links == |
| * LIGAND-RXN: | | * LIGAND-RXN: |
− | ** [http://www.genome.jp/dbget-bin/www_bget?R03876 R03876] | + | ** [http://www.genome.jp/dbget-bin/www_bget?R04319 R04319] |
− | * UNIPROT:
| + | {{#set: direction=REVERSIBLE}} |
− | ** [http://www.uniprot.org/uniprot/P22314 P22314]
| + | {{#set: common name=NAD(P)-binding domain}} |
− | ** [http://www.uniprot.org/uniprot/P49459 P49459]
| + | {{#set: ec number=EC-1.3.1.34}} |
− | ** [http://www.uniprot.org/uniprot/P62256 P62256]
| + | {{#set: gene associated=Ec-16_003950}} |
− | ** [http://www.uniprot.org/uniprot/P63146 P63146]
| + | {{#set: in pathway=}} |
− | ** [http://www.uniprot.org/uniprot/P28263 P28263]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q02053 Q02053]
| + | |
− | ** [http://www.uniprot.org/uniprot/P62257 P62257]
| + | |
− | ** [http://www.uniprot.org/uniprot/P61088 P61088]
| + | |
− | ** [http://www.uniprot.org/uniprot/P63279 P63279]
| + | |
− | ** [http://www.uniprot.org/uniprot/P19812 P19812]
| + | |
− | ** [http://www.uniprot.org/uniprot/P21734 P21734]
| + | |
− | ** [http://www.uniprot.org/uniprot/P25869 P25869]
| + | |
− | ** [http://www.uniprot.org/uniprot/P31254 P31254]
| + | |
− | ** [http://www.uniprot.org/uniprot/P15731 P15731]
| + | |
− | ** [http://www.uniprot.org/uniprot/P15732 P15732]
| + | |
− | ** [http://www.uniprot.org/uniprot/P29340 P29340]
| + | |
− | ** [http://www.uniprot.org/uniprot/P35133 P35133]
| + | |
− | ** [http://www.uniprot.org/uniprot/P35134 P35134]
| + | |
− | ** [http://www.uniprot.org/uniprot/P35132 P35132]
| + | |
− | ** [http://www.uniprot.org/uniprot/P33296 P33296]
| + | |
− | ** [http://www.uniprot.org/uniprot/P22515 P22515]
| + | |
− | ** [http://www.uniprot.org/uniprot/P39940 P39940]
| + | |
− | ** [http://www.uniprot.org/uniprot/P42748 P42748]
| + | |
− | ** [http://www.uniprot.org/uniprot/P42750 P42750]
| + | |
− | ** [http://www.uniprot.org/uniprot/P42749 P42749]
| + | |
− | ** [http://www.uniprot.org/uniprot/P42747 P42747]
| + | |
− | ** [http://www.uniprot.org/uniprot/P50623 P50623]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q42973 Q42973]
| + | |
− | ** [http://www.uniprot.org/uniprot/P40984 P40984]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q92462 Q92462]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q42540 Q42540]
| + | |
− | ** [http://www.uniprot.org/uniprot/P93028 P93028]
| + | |
− | ** [http://www.uniprot.org/uniprot/P93393 P93393]
| + | |
− | ** [http://www.uniprot.org/uniprot/P31252 P31252]
| + | |
− | ** [http://www.uniprot.org/uniprot/P52486 P52486]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q9YGM6 Q9YGM6]
| + | |
− | ** [http://www.uniprot.org/uniprot/O42646 O42646]
| + | |
− | ** [http://www.uniprot.org/uniprot/O15979 O15979]
| + | |
− | ** [http://www.uniprot.org/uniprot/P23566 P23566]
| + | |
− | ** [http://www.uniprot.org/uniprot/Q96PU5 Q96PU5]
| + | |
− | ** [http://www.uniprot.org/uniprot/P27949 P27949]
| + | |
− | {{#set: direction=LEFT-TO-RIGHT}} | + | |
− | {{#set: common name=ubiquitin-protein transferase}} | + | |
− | {{#set: common name=Ubiquitin-activating enzyme e1, C-terminal}}
| + | |
− | {{#set: common name=putative ubiquitin activating enzyme}}
| + | |
− | {{#set: common name=Ubiquitin activating enzyme (E1) subunit UBA3}}
| + | |
− | {{#set: ec number=EC-6.2.1.45}} | + | |
− | {{#set: gene associated=Ec-09_004750|Ec-13_002660|Ec-01_007490|Ec-26_001140|Ec-22_002200|Ec-01_008900|Ec-01_009550|Ec-06_002450|Ec-25_000510|Ec-25_002490|Ec-18_001830|Ec-01_001660|Ec-14_006720|Ec-25_000920|Ec-14_003730|Ec-00_007160|Ec-25_000910|Ec-09_000720|Ec-14_001990|Ec-25_002630|Ec-27_002840|Ec-01_010570|Ec-16_001360|Ec-24_003940|Ec-12_000320}} | + | |
− | {{#set: in pathway=PWY-7511}} | + | |
| {{#set: reconstruction category=annotation}} | | {{#set: reconstruction category=annotation}} |
| {{#set: reconstruction source=annotation-esiliculosus_genome}} | | {{#set: reconstruction source=annotation-esiliculosus_genome}} |
| {{#set: reconstruction tool=pathwaytools}} | | {{#set: reconstruction tool=pathwaytools}} |
Genes have been associated with this reaction based on different elements listed below.