RXN-10939

Reaction 2-ISOPROPYLMALATESYN-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • 2-Isopropylmalate synthase
• ec number:
  • EC-2.3.3.13
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 2-KETO-ISOVALERATE[c] + 1 ACETYL-COA[c] + 1 WATER[c] => 1 3-CARBOXY-3-HYDROXY-ISOCAPROATE[c] + 1 CO-A[c] + 1 PROTON[c]
• With common name(s):
  • 1 3-methyl-2-oxobutanoate[c] + 1 acetyl-CoA[c] + 1 H2O[c] => 1 (2S)-2-isopropylmalate[c] + 1 coenzyme A[c] + 1 H+[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Ec-28_002630
  • Source: annotation-esiliculosus_genome
    • Assignment: EC-NUMBER
• Gene: Ec-18_000460
  • Source: annotation-esiliculosus_genome
    • Assignment: EC-NUMBER
  • Source: orthology-aragem

Pathways

• LEUSYN-PWY, L-leucine biosynthesis: LEUSYN-PWY
  • 6 reactions found over 6 reactions in the full pathway
• PWY-6871, 3-methylbutanol biosynthesis (engineered): PWY-6871
  • 5 reactions found over 7 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-aragem
    • Tool: pantograph
• Category: annotation
  • Source: annotation-esiliculosus_genome
    • Tool: pathwaytools

External links

• RHEA:
  • 21524
• LIGAND-RXN:
  • R01213
• UNIPROT:
  • P06208
  • Q58595
  • P09151
  • Q9PLV9
  • Q9JUK6
  • Q58787
  • P94565
  • Q9JP75
  • Q02141
  • P48575
  • O86511