RXN-17008

Reaction 2OXOGLUTDECARB-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • dihydrolipoamide dehydrogenase
  • Oxoglutarate dehydrogenase, N-terminal part
  • 2-oxoglutarate dehydrogenase E1 component
• ec number:
  • EC-1.2.4.2
• Synonym(s):
  • Oxoglutarate decarboxylase
  • 2-oxoglutarate decarboxylation

Reaction Formula

• With identifiers:
  • 1 2-KETOGLUTARATE[c] + 1 PROTON[c] + 1 Oxo-glutarate-dehydrogenase-lipoyl[c] => 1 CARBON-DIOXIDE[c] + 1 Oxo-glutarate-dehydro-suc-DH-lipoyl[c]
• With common name(s):
  • 1 2-oxoglutarate[c] + 1 H+[c] + 1 a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine[c] => 1 CO2[c] + 1 a [2-oxoglutarate dehydrogenase E2 protein] N6-S-succinyldihydrolipoyl-L-lysine[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Ec-25_000020
  • Source: annotation-esiliculosus_genome
    • Assignment: AUTOMATED-NAME-MATCH
• Gene: Ec-21_002310
  • Source: annotation-esiliculosus_genome
    • Assignment: EC-NUMBER
• Gene: Ec-21_002300
  • Source: annotation-esiliculosus_genome
    • Assignment: EC-NUMBER
• Gene: Ec-27_004160
  • Source: annotation-esiliculosus_genome
    • Assignment: AUTOMATED-NAME-MATCH

Pathways

• PWY-5084, 2-oxoglutarate decarboxylation to succinyl-CoA: PWY-5084
  • 3 reactions found over 3 reactions in the full pathway
• PWY66-398, TCA cycle III (animals): PWY66-398
  • 10 reactions found over 11 reactions in the full pathway

Reconstruction information

• Category: annotation
  • Source: annotation-esiliculosus_genome
    • Tool: pathwaytools

External links

• UNIPROT:
  • P23129
  • Q02218
  • Q60597
  • Q9JRJ8
  • P20967
  • P0AFG3
  • P20707
  • P51056
  • Q56600
  • O49541
  • Q59106
  • Q9M2T8
  • Q9ZRQ2