RXN0-2142

Reaction HOMOCYSMET-RXN

• direction:
  • REVERSIBLE
• common name:
  • 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
  • Methionine synthase
• ec number:
  • EC-2.1.1.14
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 CPD-1302[c] + 1 HOMO-CYS[c] <=> 1 MET[c] + 1 CPD-1301[c]
• With common name(s):
  • 1 N5-methyl--tetrahydropteroyl tri-L-glutamate[c] + 1 L-homocysteine[c] <=> 1 L-methionine[c] + 1 tetrahydropteroyl tri-L-glutamate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Ec-28_003190
  • ESILICULOSUS_GENOME
    • EC-NUMBER
  • pantograph-aragem
• Ec-06_000970
  • ESILICULOSUS_GENOME
    • AUTOMATED-NAME-MATCH

Pathways

• HOMOSER-METSYN-PWY, L-methionine biosynthesis I: HOMOSER-METSYN-PWY
  • 5 reactions found over 5 reactions in the full pathway
• PWY-702, L-methionine biosynthesis II: PWY-702
  • 6 reactions found over 6 reactions in the full pathway
• HSERMETANA-PWY, L-methionine biosynthesis III: HSERMETANA-PWY
  • 2 reactions found over 4 reactions in the full pathway
• PWY-6151, S-adenosyl-L-methionine cycle I: PWY-6151
  • 3 reactions found over 6 reactions in the full pathway
• PWY-5041, S-adenosyl-L-methionine cycle II: PWY-5041
  • 3 reactions found over 4 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-aragem
    • Tool: pantograph
• Category: annotation
  • Source: annotation-esiliculosus_genome
    • Tool: pathwaytools

External links

• RHEA:
  • 21196
• LIGAND-RXN:
  • R04405
• UNIPROT:
  • P25665
  • P45331
  • Q9PN94
  • O26869
  • Q9JUT6
  • Q9CG55
  • P05694
  • Q42699
  • Q39586
  • O48613
  • P93263
  • Q9UT19