RXN-7645

Reaction GLYOHMETRANS-RXN

• direction:
  • REVERSIBLE
• common name:
  • Serine hydroxymethyltransferase
  • glycine hydroxymethyltransferase
• ec number:
  • EC-2.1.2.1
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 SER[c] + 1 THF-GLU-N[c] <=> 1 WATER[c] + 1 METHYLENE-THF-GLU-N[c] + 1 GLY[c]
• With common name(s):
  • 1 L-serine[c] + 1 a tetrahydrofolate[c] <=> 1 H2O[c] + 1 a 5,10-methylene-tetrahydrofolate[c] + 1 glycine[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Ec-14_004260
  • Source: annotation-esiliculosus_genome
    • Assignment: GO-TERM
• Gene: Ec-24_002640
  • Source: annotation-esiliculosus_genome
    • Assignment: EC-NUMBER

Pathways

• PWY-2161, folate polyglutamylation: PWY-2161
  • 5 reactions found over 5 reactions in the full pathway
• PWY-1622, formaldehyde assimilation I (serine pathway): PWY-1622
  • 6 reactions found over 13 reactions in the full pathway
• PWY-3841, folate transformations II: PWY-3841
  • 10 reactions found over 11 reactions in the full pathway
• 1CMET2-PWY, N10-formyl-tetrahydrofolate biosynthesis: 1CMET2-PWY
  • 9 reactions found over 9 reactions in the full pathway
• PWY-3661, glycine betaine degradation I: PWY-3661
  • 3 reactions found over 7 reactions in the full pathway
• GLYSYN-PWY, glycine biosynthesis I: GLYSYN-PWY
  • 1 reactions found over 1 reactions in the full pathway
• PWY-5497, purine nucleobases degradation II (anaerobic): PWY-5497
  • 8 reactions found over 24 reactions in the full pathway
• PWY-2201, folate transformations I: PWY-2201
  • 12 reactions found over 12 reactions in the full pathway
• PWY-181, photorespiration: PWY-181
  • 6 reactions found over 9 reactions in the full pathway
• PWY-3661-1, glycine betaine degradation II (mammalian): PWY-3661-1
  • 1 reactions found over 4 reactions in the full pathway

Reconstruction information

• Category: annotation
  • Source: annotation-esiliculosus_genome
    • Tool: pathwaytools

External links

• RHEA:
  • 15481
• LIGAND-RXN:
  • R00945
• UNIPROT:
  • P35623
  • P34898
  • P34899
  • P34896
  • Q9CHW7
  • P34897
  • P0A2E1
  • O23254
  • O53441
  • O08370
  • P43844
  • Q58992
  • O66776
  • Q9XAY7
  • P47634
  • Q9WZH9
  • P56089
  • O53615
  • O83349
  • Q9ZMP7
  • O51547
  • O84439
  • P24531
  • P39148
  • P24060
  • P37292
  • P34895
  • P34894
  • P49357
  • P49358
  • P50433
  • P37291
  • P78011
  • P77962
  • Q9SVM4
  • Q9SUU0
  • Q9SZJ5
  • O23984
  • P0A825
  • P07511