DHFR

Reaction DHFR

• direction:
  • REVERSIBLE
• common name:
  • Dihydrofolate reductase
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1.0 h[c] + 1.0 dhf[c] + 1.0 nadph[c] <=> 1.0 thf[c] + 1.0 nadp[c]
• With common name(s):
  • 1.0 H+[c] + 1.0 7,8-Dihydrofolate[c] + 1.0 Nicotinamide adenine dinucleotide phosphate - reduced[c] <=> 1.0 5,6,7,8-Tetrahydrofolate[c] + 1.0 Nicotinamide adenine dinucleotide phosphate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: EF1577
  • Source: orthology-l_plantarum_wcfs1
  • Source: orthology-e_coli_sstr_k12_substr_mg1655
  • Source: orthology-b_subtilis_subsp_subtilis_str168

Pathways

• map01100: map01100
  • 460 reactions found over 2349 reactions in the full pathway
• map00670: map00670
  • 14 reactions found over 65 reactions in the full pathway
• map00790: map00790
  • 12 reactions found over 41 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-e_coli_sstr_k12_substr_mg1655
    • Tool: pantograph
  • Source: orthology-b_subtilis_subsp_subtilis_str168
    • Tool: pantograph
  • Source: orthology-l_plantarum_wcfs1
    • Tool: pantograph

External links

• RHEA:
  • 15009
• Reactome : REACT_R-BTA-197972
• MetaNetX (MNX) Equation : MNXR97401
• KEGG Reaction : R00939
• EC Number : 1.5.1.3