DIHYDROFOLATEREDUCT-RXN

Reaction DIHYDROFOLATEREDUCT-RXN

• direction:
  • LEFT-TO-RIGHT
• ec number:
  • EC-1.5.1.3
• common name:
  • dihydrofolate reductase
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 DIHYDROFOLATE-GLU-N[c] + 1 NADPH[c] + 1 PROTON[c] => 1 THF-GLU-N[c] + 1 NADP[c]
• With common name(s):
  • 1 a 7,8-dihydrofolate[c] + 1 NADPH[c] + 1 H+[c] => 1 a tetrahydrofolate[c] + 1 NADP+[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: SJ19601
  • Source: annotation-saccharina_japonica_genome
    • Assignment: EC-NUMBER
  • Source: orthology-ectocarpus_siliculosus
• Gene: SJ11954
  • Source: orthology-ectocarpus_siliculosus
• Gene: SJ02922
  • Source: orthology-ectocarpus_siliculosus
• Gene: SJ17385
  • Source: orthology-ectocarpus_siliculosus

Pathways

• 1CMET2-PWY, N10-formyl-tetrahydrofolate biosynthesis: 1CMET2-PWY
  • 8 reactions found over 9 reactions in the full pathway
• PWY-6614, tetrahydrofolate biosynthesis: PWY-6614
  • 3 reactions found over 3 reactions in the full pathway
• PWY-3841, folate transformations II: PWY-3841
  • 9 reactions found over 11 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-ectocarpus_siliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-saccharina_japonica_genome
    • Tool: pathwaytools

External links

• RHEA:
  • 15011
• LIGAND-RXN:
  • R00939