RXN-13162

Reaction RXN-13162

• direction:
  • LEFT-TO-RIGHT
• ec number:
  • EC-2.5.1.21
• common name:
  • squalene synthase
  • farnesyl-diphosphate farnesyltransferase
• Synonym(s):

Reaction Formula

• With identifiers:
  • 2 FARNESYL-PP[c] + 1 NADH-P-OR-NOP[c] + 1 PROTON[c] => 1 SQUALENE[c] + 2 PPI[c] + 1 NAD-P-OR-NOP[c]
• With common name(s):
  • 2 (2E,6E)-farnesyl diphosphate[c] + 1 NAD(P)H[c] + 1 H+[c] => 1 squalene[c] + 2 diphosphate[c] + 1 NAD(P)+[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: SJ13532
  • Source: annotation-saccharina_japonica_genome
    • Assignment: EC-NUMBER
  • Source: orthology-ectocarpus_siliculosus
• Gene: SJ02885
  • Source: annotation-saccharina_japonica_genome
    • Assignment: GO-TERM

Pathways

• PWY-5670, epoxysqualene biosynthesis: PWY-5670
  • 2 reactions found over 2 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-ectocarpus_siliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-saccharina_japonica_genome
    • Tool: pathwaytools

External links

• RHEA:
  • 32302
  • 32296
• LIGAND-RXN:
  • R06223