RXN-8661

Reaction RXN-8661

• direction:
  • LEFT-TO-RIGHT
• ec number:
  • EC-1.14.11
• common name:
  • [histone-H3]-lysine-36 demethylase
  • histone demethylase activity (H3-K36 specific)
• Synonym(s):
  • JHDM1A
  • JmjC domain-containing histone demethylase 1A
  • H3-K36-specific demethylase
  • histone-lysine (H3-K36) demethylase
  • histone demethylase
  • protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase

Reaction Formula

• With identifiers:
  • 1 PROTON[c] + 1 OXYGEN-MOLECULE[c] + 1 2-KETOGLUTARATE[c] + 1 CPD-8901[c] => 1 CARBON-DIOXIDE[c] + 1 Protein-L-lysine[c] + 1 SUC[c] + 1 FORMALDEHYDE[c]
• With common name(s):
  • 1 H+[c] + 1 oxygen[c] + 1 2-oxoglutarate[c] + 1 a [protein] N6-methyl-L-lysine[c] => 1 CO2[c] + 1 a [protein]-L-lysine[c] + 1 succinate[c] + 1 formaldehyde[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: SJ18735
  • Source: annotation-saccharina_japonica_genome
    • Assignment: EC-NUMBER
• Gene: SJ05371
  • Source: annotation-saccharina_japonica_genome
    • Assignment: EC-NUMBER
• Gene: SJ19102
  • Source: annotation-saccharina_japonica_genome
    • Assignment: EC-NUMBER
• Gene: SJ00708
  • Source: annotation-saccharina_japonica_genome
    • Assignment: GO-TERM
• Gene: SJ13421
  • Source: annotation-saccharina_japonica_genome
    • Assignment: EC-NUMBER
• Gene: SJ19354
  • Source: annotation-saccharina_japonica_genome
    • Assignment: GO-TERM

Reconstruction information

• Category: annotation
  • Source: annotation-saccharina_japonica_genome
    • Tool: pathwaytools

External links

• RHEA:
  • 10785

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