RXN-8991

Reaction RXN-8991

• direction:
  • REVERSIBLE
• common name:
  • 3-isopropylmalate dehydratase
  • (2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
• Synonym(s):
  • (2R,3S)-3-isopropylmalate hydro-lyase
  • β-isopropylmalate dehydratase
  • α-isopropylmalate isomerase
  • 3-isopropylmalate hydro-lyase

Reaction Formula

• With identifiers:
  • 1 2-D-THREO-HYDROXY-3-CARBOXY-ISOCAPROATE[c] <=> 1 WATER[c] + 1 CPD-9451[c]
• With common name(s):
  • 1 (2R,3S)-3-isopropylmalate[c] <=> 1 H2O[c] + 1 2-isopropylmaleate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: SJ22396
  • Source: annotation-saccharina_japonica_genome
    • Assignment: EC-NUMBER
  • Source: orthology-arabidopsis_thaliana
  • Source: orthology-ectocarpus_siliculosus
• Gene: SJ09771
  • Source: annotation-saccharina_japonica_genome
    • Assignment: EC-NUMBER
  • Source: orthology-arabidopsis_thaliana
  • Source: orthology-ectocarpus_siliculosus

Pathways

• LEUSYN-PWY, L-leucine biosynthesis: LEUSYN-PWY
  • 5 reactions found over 6 reactions in the full pathway
• PWY-6871, 3-methylbutanol biosynthesis (engineered): PWY-6871
  • 5 reactions found over 7 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-arabidopsis_thaliana
    • Tool: pantograph
  • Source: orthology-ectocarpus_siliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-saccharina_japonica_genome
    • Tool: pathwaytools

External links

• RHEA:
  • 10676
• LIGAND-RXN:
  • R04001