View source for Damaged-DNA-Pyrimidine

[[Category:Reaction]]
== Reaction [http://metacyc.org/META/NEW-IMAGE?object=HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN] ==
* direction:
** LEFT-TO-RIGHT
* ec number:
** [http://enzyme.expasy.org/EC/4.1.3.4 EC-4.1.3.4]
* Synonym(s):

== Reaction Formula ==
* With identifiers:
** 1 [[3-HYDROXY-3-METHYL-GLUTARYL-COA]][c] '''=>''' 1 [[ACETYL-COA]][c] '''+''' 1 [[3-KETOBUTYRATE]][c]
* With common name(s):
** 1 (S)-3-hydroxy-3-methylglutaryl-CoA[c] '''=>''' 1 acetyl-CoA[c] '''+''' 1 acetoacetate[c]

== Genes associated with this reaction  ==
Genes have been associated with this reaction based on different elements listed below.
* [[Tiso_gene_3769]]
** [[pantograph]]-[[athaliana]]
** [[pantograph]]-[[esiliculosus]]
== Pathways  ==
* [[PWY66-367]], ketogenesis: [http://metacyc.org/META/NEW-IMAGE?object=PWY66-367 PWY66-367]
** '''5''' reactions found over '''5''' reactions in the full pathway
* [[LEU-DEG2-PWY]], L-leucine degradation I: [http://metacyc.org/META/NEW-IMAGE?object=LEU-DEG2-PWY LEU-DEG2-PWY]
** '''6''' reactions found over '''6''' reactions in the full pathway
* [[PWY-5074]], mevalonate degradation: [http://metacyc.org/META/NEW-IMAGE?object=PWY-5074 PWY-5074]
** '''1''' reactions found over '''2''' reactions in the full pathway
== Reconstruction information  ==
* Category: [[orthology]]
** Source: [[orthology-athaliana]]
*** Tool: [[pantograph]]
** Source: [[orthology-esiliculosus]]
*** Tool: [[pantograph]]
* Category: [[annotation]]
** Source: [[annotation-experimental_annotation]]
*** Tool: [[pathwaytools]]
** Source: [[annotation-in-silico_annotation]]
*** Tool: [[pathwaytools]]
== External links  ==
* RHEA:
** [http://www.ebi.ac.uk/rhea/reaction.xhtml?id=24404 24404]
* LIGAND-RXN:
** [http://www.genome.jp/dbget-bin/www_bget?R01360 R01360]
* UNIPROT:
** [http://www.uniprot.org/uniprot/P35914 P35914]
** [http://www.uniprot.org/uniprot/P35915 P35915]
** [http://www.uniprot.org/uniprot/Q8L7K2 Q8L7K2]
{{#set: direction=LEFT-TO-RIGHT}}
{{#set: ec number=EC-4.1.3.4}}
{{#set: gene associated=Tiso_gene_3769}}
{{#set: in pathway=PWY66-367|LEU-DEG2-PWY|PWY-5074}}
{{#set: reconstruction category=orthology|annotation}}
{{#set: reconstruction source=annotation-experimental_annotation|orthology-athaliana|annotation-in-silico_annotation|orthology-esiliculosus}}
{{#set: reconstruction tool=pantograph|pathwaytools}}