Difference between revisions of "THYROXINE-DEIODINASE-RXN"

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(Created page with "Category:Metabolite == Metabolite [http://metacyc.org/META/NEW-IMAGE?object=SUC-COA SUC-COA] == * smiles: ** CC(C)(C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)[O-])COP(=O)(OP(=O)(OCC...")
(Created page with "Category:Reaction == Reaction [http://metacyc.org/META/NEW-IMAGE?object=THYROXINE-DEIODINASE-RXN THYROXINE-DEIODINASE-RXN] == * direction: ** LEFT-TO-RIGHT * common name:...")
 
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[[Category:Metabolite]]
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[[Category:Reaction]]
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== Metabolite [http://metacyc.org/META/NEW-IMAGE?object=SUC-COA SUC-COA] ==
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== Reaction [http://metacyc.org/META/NEW-IMAGE?object=THYROXINE-DEIODINASE-RXN THYROXINE-DEIODINASE-RXN] ==
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* smiles:
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* direction:
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** CC(C)(C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)[O-])COP(=O)(OP(=O)(OCC1(C(OP([O-])(=O)[O-])C(O)C(O1)N3(C2(=C(C(N)=NC=N2)N=C3))))[O-])[O-]
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** LEFT-TO-RIGHT
 
* common name:
 
* common name:
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** succinyl-CoA
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** type_i_iodothyronine_deiodinase
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* inchi key:
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* ec number:
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** InChIKey=VNOYUJKHFWYWIR-ITIYDSSPSA-I
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** [http://enzyme.expasy.org/EC/1.21.99.4 EC-1.21.99.4]
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* molecular weight:
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** 862.568   
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* Synonym(s):
 
* Synonym(s):
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** suc-coa
 
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** succ-coenzyme-A
 
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** succ-S-coenzyme-A
 
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** succinyl-S-coenzyme-A
 
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** succ-S-CoA
 
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** succinylcoenzyme-A
 
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** succ-CoA
 
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** suc-co-A
 
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** succinyl-S-CoA
 
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** succinyl-coenzyme A
 
  
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== Reaction(s) known to consume the compound ==
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== Reaction Formula ==
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== Reaction(s) known to produce the compound ==
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* With identifiers:
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== Reaction(s) of unknown directionality ==
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** 1 [[L-THYROXINE]][c] '''+''' 1 [[Donor-H2]][c] '''=>''' 1 [[CPD-387]][c] '''+''' 1 [[PROTON]][c] '''+''' 1 [[Acceptor]][c] '''+''' 1 [[LIOTHYRONINE]][c]
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* [[3-OXOACID-COA-TRANSFERASE-RXN]]
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* With common name(s):
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* [[RXN0-1147]]
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** 1 L-thyroxine[c] '''+''' 1 a reduced electron acceptor[c] '''=>''' 1 iodide[c] '''+''' 1 H+[c] '''+''' 1 an oxidized electron acceptor[c] '''+''' 1 3,5,3'-triiodo-L-thyronine[c]
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* [[SUCL_gdp_m]]
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* [[RXNI-2]]
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== Genes associated with this reaction  ==
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* [[SUCCINATE--COA-LIGASE-GDP-FORMING-RXN]]
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Genes have been associated with this reaction based on different elements listed below.
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* [[SUCCCOASYN-RXN]]
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* Gene: [[Tiso_gene_20481]]
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* [[METHYLMALONYL-COA-MUT-RXN]]
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** Source: [[annotation-in-silico_annotation]]
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* [[AKGDHe2r]]
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*** Assignment: EC-NUMBER
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== Pathways  ==
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* [[PWY-6261]], thyroid hormone metabolism II (via conjugation and/or degradation): [http://metacyc.org/META/NEW-IMAGE?object=PWY-6261 PWY-6261]
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** '''11''' reactions found over '''15''' reactions in the full pathway
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* [[PWY-6260]], thyroid hormone metabolism I (via deiodination): [http://metacyc.org/META/NEW-IMAGE?object=PWY-6260 PWY-6260]
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** '''3''' reactions found over '''12''' reactions in the full pathway
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== Reconstruction information  ==
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* Category: [[annotation]]
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** Source: [[annotation-in-silico_annotation]]
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*** Tool: [[pathwaytools]]
 
== External links  ==
 
== External links  ==
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* CAS : 604-98-8
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* RHEA:
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* BIGG : succoa
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** [http://www.ebi.ac.uk/rhea/reaction.xhtml?id=19745 19745]
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* PUBCHEM:
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* LIGAND-RXN:
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** [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=45266545 45266545]
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** [http://www.genome.jp/dbget-bin/www_bget?R03734 R03734]
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* HMDB : HMDB01022
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* UNIPROT:
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* LIGAND-CPD:
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** [http://www.uniprot.org/uniprot/P21195 P21195]
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** [http://www.genome.jp/dbget-bin/www_bget?C00091 C00091]
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** [http://www.uniprot.org/uniprot/P49897 P49897]
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* CHEBI:
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** [http://www.uniprot.org/uniprot/P49898 P49898]
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** [http://www.ebi.ac.uk/chebi/searchId.do?chebiId=57292 57292]
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** [http://www.uniprot.org/uniprot/P05307 P05307]
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* METABOLIGHTS : MTBLC57292
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** [http://www.uniprot.org/uniprot/P09102 P09102]
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{{#set: smiles=CC(C)(C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)[O-])COP(=O)(OP(=O)(OCC1(C(OP([O-])(=O)[O-])C(O)C(O1)N3(C2(=C(C(N)=NC=N2)N=C3))))[O-])[O-]}}
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** [http://www.uniprot.org/uniprot/P07237 P07237]
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{{#set: common name=succinyl-CoA}}
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** [http://www.uniprot.org/uniprot/Q922C8 Q922C8]
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{{#set: inchi key=InChIKey=VNOYUJKHFWYWIR-ITIYDSSPSA-I}}
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** [http://www.uniprot.org/uniprot/P04785 P04785]
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{{#set: molecular weight=862.568    }}
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** [http://www.uniprot.org/uniprot/P24389 P24389]
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{{#set: common name=suc-coa|succ-coenzyme-A|succ-S-coenzyme-A|succinyl-S-coenzyme-A|succ-S-CoA|succinylcoenzyme-A|succ-CoA|suc-co-A|succinyl-S-CoA|succinyl-coenzyme A}}
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{{#set: direction=LEFT-TO-RIGHT}}
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{{#set: reversible reaction associated=3-OXOACID-COA-TRANSFERASE-RXN|RXN0-1147|SUCL_gdp_m|RXNI-2|SUCCINATE--COA-LIGASE-GDP-FORMING-RXN|SUCCCOASYN-RXN|METHYLMALONYL-COA-MUT-RXN|AKGDHe2r}}
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{{#set: common name=type_i_iodothyronine_deiodinase}}
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{{#set: ec number=EC-1.21.99.4}}
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{{#set: gene associated=Tiso_gene_20481}}
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{{#set: in pathway=PWY-6261|PWY-6260}}
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{{#set: reconstruction category=annotation}}
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{{#set: reconstruction source=annotation-in-silico_annotation}}
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{{#set: reconstruction tool=pathwaytools}}

Latest revision as of 20:25, 21 March 2018

Reaction THYROXINE-DEIODINASE-RXN

  • direction:
    • LEFT-TO-RIGHT
  • common name:
    • type_i_iodothyronine_deiodinase
  • ec number:
  • Synonym(s):

Reaction Formula

  • With identifiers:
  • With common name(s):
    • 1 L-thyroxine[c] + 1 a reduced electron acceptor[c] => 1 iodide[c] + 1 H+[c] + 1 an oxidized electron acceptor[c] + 1 3,5,3'-triiodo-L-thyronine[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

Pathways

  • PWY-6261, thyroid hormone metabolism II (via conjugation and/or degradation): PWY-6261
    • 11 reactions found over 15 reactions in the full pathway
  • PWY-6260, thyroid hormone metabolism I (via deiodination): PWY-6260
    • 3 reactions found over 12 reactions in the full pathway

Reconstruction information

External links





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