Difference between revisions of "THYMIDYLATESYN-RXN"

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(Created page with "Category:Metabolite == Metabolite [http://metacyc.org/META/NEW-IMAGE?object=CPD-414 CPD-414] == * smiles: ** CC(NC1(C(CC(OC1C(O)C(O)CO)(C([O-])=O)O)OC(C)=O))=O * common na...")
(Created page with "Category:Reaction == Reaction [http://metacyc.org/META/NEW-IMAGE?object=THYMIDYLATESYN-RXN THYMIDYLATESYN-RXN] == * direction: ** LEFT-TO-RIGHT * common name: ** thymidyla...")
 
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[[Category:Metabolite]]
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[[Category:Reaction]]
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== Metabolite [http://metacyc.org/META/NEW-IMAGE?object=CPD-414 CPD-414] ==
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== Reaction [http://metacyc.org/META/NEW-IMAGE?object=THYMIDYLATESYN-RXN THYMIDYLATESYN-RXN] ==
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* smiles:
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* direction:
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** CC(NC1(C(CC(OC1C(O)C(O)CO)(C([O-])=O)O)OC(C)=O))=O
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** LEFT-TO-RIGHT
 
* common name:
 
* common name:
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** N-acetyl-4-O-acetylneuraminate
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** thymidylate_synthase
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* inchi key:
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** ORF
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** InChIKey=LVBIMVQYUKOENY-FODKYPIKSA-M
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* ec number:
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* molecular weight:
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** [http://enzyme.expasy.org/EC/2.1.1.45 EC-2.1.1.45]
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** 350.302   
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* Synonym(s):
 
* Synonym(s):
  
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== Reaction(s) known to consume the compound ==
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== Reaction Formula ==
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* [[RXN-13181]]
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* With identifiers:
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== Reaction(s) known to produce the compound ==
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** 1 [[DUMP]][c] '''+''' 1 [[METHYLENE-THF-GLU-N]][c] '''=>''' 1 [[TMP]][c] '''+''' 1 [[DIHYDROFOLATE-GLU-N]][c]
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== Reaction(s) of unknown directionality ==
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* With common name(s):
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** 1 dUMP[c] '''+''' 1 a 5,10-methylene-tetrahydrofolate[c] '''=>''' 1 dTMP[c] '''+''' 1 a 7,8-dihydrofolate[c]
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== Genes associated with this reaction  ==
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Genes have been associated with this reaction based on different elements listed below.
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* Gene: [[Tiso_gene_7708]]
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** Source: [[annotation-in-silico_annotation]]
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*** Assignment: EC-NUMBER
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* Gene: [[Tiso_gene_18478]]
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** Source: [[annotation-in-silico_annotation]]
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*** Assignment: EC-NUMBER
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== Pathways  ==
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* [[PWY-7210]], pyrimidine deoxyribonucleotides biosynthesis from CTP: [http://metacyc.org/META/NEW-IMAGE?object=PWY-7210 PWY-7210]
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** '''8''' reactions found over '''8''' reactions in the full pathway
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* [[PWY-7198]], pyrimidine deoxyribonucleotides de novo biosynthesis IV: [http://metacyc.org/META/NEW-IMAGE?object=PWY-7198 PWY-7198]
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** '''6''' reactions found over '''7''' reactions in the full pathway
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* [[PWY-7199]], pyrimidine deoxyribonucleosides salvage: [http://metacyc.org/META/NEW-IMAGE?object=PWY-7199 PWY-7199]
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** '''1''' reactions found over '''5''' reactions in the full pathway
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* [[PWY-3841]], folate transformations II: [http://metacyc.org/META/NEW-IMAGE?object=PWY-3841 PWY-3841]
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** '''9''' reactions found over '''11''' reactions in the full pathway
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* [[1CMET2-PWY]], N10-formyl-tetrahydrofolate biosynthesis: [http://metacyc.org/META/NEW-IMAGE?object=1CMET2-PWY 1CMET2-PWY]
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** '''7''' reactions found over '''9''' reactions in the full pathway
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* [[PWY-7187]], pyrimidine deoxyribonucleotides de novo biosynthesis II: [http://metacyc.org/META/NEW-IMAGE?object=PWY-7187 PWY-7187]
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** '''4''' reactions found over '''7''' reactions in the full pathway
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* [[PWY0-166]], superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli): [http://metacyc.org/META/NEW-IMAGE?object=PWY0-166 PWY0-166]
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** '''12''' reactions found over '''17''' reactions in the full pathway
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* [[PWY-7184]], pyrimidine deoxyribonucleotides de novo biosynthesis I: [http://metacyc.org/META/NEW-IMAGE?object=PWY-7184 PWY-7184]
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** '''9''' reactions found over '''9''' reactions in the full pathway
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== Reconstruction information  ==
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* Category: [[manual]]
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** Source: [[manual-primary_network]]
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* Category: [[annotation]]
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** Source: [[annotation-in-silico_annotation]]
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*** Tool: [[pathwaytools]]
 
== External links  ==
 
== External links  ==
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* PUBCHEM:
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* RHEA:
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** [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=25244557 25244557]
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** [http://www.ebi.ac.uk/rhea/reaction.xhtml?id=12104 12104]
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* HMDB : HMDB00796
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* LIGAND-RXN:
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* CHEBI:
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** [http://www.genome.jp/dbget-bin/www_bget?R02101 R02101]
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** [http://www.ebi.ac.uk/chebi/searchId.do?chebiId=29006 29006]
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* UNIPROT:
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* LIGAND-CPD:
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** [http://www.uniprot.org/uniprot/P19368 P19368]
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** [http://www.genome.jp/dbget-bin/www_bget?C04015 C04015]
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** [http://www.uniprot.org/uniprot/Q07422 Q07422]
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{{#set: smiles=CC(NC1(C(CC(OC1C(O)C(O)CO)(C([O-])=O)O)OC(C)=O))=O}}
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** [http://www.uniprot.org/uniprot/P47469 P47469]
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{{#set: common name=N-acetyl-4-O-acetylneuraminate}}
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** [http://www.uniprot.org/uniprot/Q9JT57 Q9JT57]
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{{#set: inchi key=InChIKey=LVBIMVQYUKOENY-FODKYPIKSA-M}}
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** [http://www.uniprot.org/uniprot/P42326 P42326]
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{{#set: molecular weight=350.302    }}
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** [http://www.uniprot.org/uniprot/O02604 O02604]
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{{#set: consumed by=RXN-13181}}
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** [http://www.uniprot.org/uniprot/P07382 P07382]
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** [http://www.uniprot.org/uniprot/P16126 P16126]
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** [http://www.uniprot.org/uniprot/P13922 P13922]
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** [http://www.uniprot.org/uniprot/P20712 P20712]
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** [http://www.uniprot.org/uniprot/P11044 P11044]
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** [http://www.uniprot.org/uniprot/P45350 P45350]
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** [http://www.uniprot.org/uniprot/P45352 P45352]
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** [http://www.uniprot.org/uniprot/P51820 P51820]
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** [http://www.uniprot.org/uniprot/P0C0M4 P0C0M4]
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** [http://www.uniprot.org/uniprot/Q27828 Q27828]
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** [http://www.uniprot.org/uniprot/P09249 P09249]
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** [http://www.uniprot.org/uniprot/P12462 P12462]
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** [http://www.uniprot.org/uniprot/P07606 P07606]
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** [http://www.uniprot.org/uniprot/P00471 P00471]
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** [http://www.uniprot.org/uniprot/P0A884 P0A884]
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** [http://www.uniprot.org/uniprot/P00469 P00469]
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** [http://www.uniprot.org/uniprot/O81395 O81395]
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** [http://www.uniprot.org/uniprot/Q05763 Q05763]
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** [http://www.uniprot.org/uniprot/Q39687 Q39687]
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** [http://www.uniprot.org/uniprot/Q9YTJ6 Q9YTJ6]
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** [http://www.uniprot.org/uniprot/P06785 P06785]
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** [http://www.uniprot.org/uniprot/P04818 P04818]
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** [http://www.uniprot.org/uniprot/P07607 P07607]
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** [http://www.uniprot.org/uniprot/P13100 P13100]
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{{#set: direction=LEFT-TO-RIGHT}}
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{{#set: common name=thymidylate_synthase}}
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{{#set: common name=ORF}}
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{{#set: ec number=EC-2.1.1.45}}
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{{#set: gene associated=Tiso_gene_7708|Tiso_gene_18478}}
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{{#set: in pathway=PWY-7210|PWY-7198|PWY-7199|PWY-3841|1CMET2-PWY|PWY-7187|PWY0-166|PWY-7184}}
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{{#set: reconstruction category=manual|annotation}}
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{{#set: reconstruction source=manual-primary_network|annotation-in-silico_annotation}}
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{{#set: reconstruction tool=pathwaytools}}

Latest revision as of 20:08, 21 March 2018

Reaction THYMIDYLATESYN-RXN

  • direction:
    • LEFT-TO-RIGHT
  • common name:
    • thymidylate_synthase
    • ORF
  • ec number:
  • Synonym(s):

Reaction Formula

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

Pathways

  • PWY-7210, pyrimidine deoxyribonucleotides biosynthesis from CTP: PWY-7210
    • 8 reactions found over 8 reactions in the full pathway
  • PWY-7198, pyrimidine deoxyribonucleotides de novo biosynthesis IV: PWY-7198
    • 6 reactions found over 7 reactions in the full pathway
  • PWY-7199, pyrimidine deoxyribonucleosides salvage: PWY-7199
    • 1 reactions found over 5 reactions in the full pathway
  • PWY-3841, folate transformations II: PWY-3841
    • 9 reactions found over 11 reactions in the full pathway
  • 1CMET2-PWY, N10-formyl-tetrahydrofolate biosynthesis: 1CMET2-PWY
    • 7 reactions found over 9 reactions in the full pathway
  • PWY-7187, pyrimidine deoxyribonucleotides de novo biosynthesis II: PWY-7187
    • 4 reactions found over 7 reactions in the full pathway
  • PWY0-166, superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli): PWY0-166
    • 12 reactions found over 17 reactions in the full pathway
  • PWY-7184, pyrimidine deoxyribonucleotides de novo biosynthesis I: PWY-7184
    • 9 reactions found over 9 reactions in the full pathway

Reconstruction information

External links





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