RXN0-5226

Reaction OHMETHYLBILANESYN-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • hydroxymethylbilane_synthase
  • uroporphyrinogen_synthase
• ec number:
  • EC-2.5.1.61
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 WATER[c] + 4 PORPHOBILINOGEN[c] => 4 AMMONIUM[c] + 1 HYDROXYMETHYLBILANE[c]
• With common name(s):
  • 1 H2O[c] + 4 porphobilinogen[c] => 4 ammonium[c] + 1 preuroporphyrinogen[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Tiso_gene_11630
  • IN-SILICO_ANNOTATION
    • AUTOMATED-NAME-MATCH
• Tiso_gene_14709
  • IN-SILICO_ANNOTATION
    • EC-NUMBER
  • EXPERIMENTAL_ANNOTATION
    • EC-NUMBER
  • pantograph-athaliana
  • pantograph-synechocystis
  • pantograph-esiliculosus
  • pantograph-creinhardtii

Pathways

• PWY-5189, tetrapyrrole biosynthesis II (from glycine): PWY-5189
  • 3 reactions found over 4 reactions in the full pathway
• PWY-5188, tetrapyrrole biosynthesis I (from glutamate): PWY-5188
  • 6 reactions found over 6 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-athaliana
    • Tool: pantograph
  • Source: orthology-creinhardtii
    • Tool: pantograph
  • Source: orthology-synechocystis
    • Tool: pantograph
  • Source: orthology-esiliculosus
    • Tool: pantograph
• Category: manual
  • Source: manual-primary_network
• Category: annotation
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools
  • Source: annotation-experimental_annotation
    • Tool: pathwaytools

External links

• RHEA:
  • 13185
• LIGAND-RXN:
  • R00084
• UNIPROT:
  • Q57989
  • O29026
  • P64336
  • Q9ZMJ7
  • Q9PHW9
  • Q9JVS4
  • P28464
  • Q9K0P6
  • P56140
  • Q9Y9J0
  • Q9RRY0
  • O26960
  • Q9ZD77
  • P06983
  • P13446
  • P08397
  • P22907
  • P19356
  • Q43082
  • P40129
  • P30527
  • P28789
  • Q60169
  • Q43316
  • Q49808
  • P73660
  • Q9WX16
  • Q09899
  • Q9ZND1