RXN-16622

Reaction RXN-12037

• direction:
  • LEFT-TO-RIGHT
• common name:
  • 3',5'-diiodothyronine 5'-deiodinase
  • type_i_iodothyronine_deiodinase
• ec number:
  • EC-1.21.99.4
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 Donor-H2[c] + 1 CPD-13008[c] => 1 CPD-387[c] + 1 PROTON[c] + 1 CPD-13010[c] + 1 Acceptor[c]
• With common name(s):
  • 1 a reduced electron acceptor[c] + 1 3',5'-diiodothyronine[c] => 1 iodide[c] + 1 H+[c] + 1 3'-monoiodothyronine[c] + 1 an oxidized electron acceptor[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Tiso_gene_20481
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER

Pathways

• PWY-6260, thyroid hormone metabolism I (via deiodination): PWY-6260
  • 3 reactions found over 12 reactions in the full pathway

Reconstruction information

• Category: annotation
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools