RXN-9650

Reaction HOMOCYSMETB12-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • ORF
• ec number:
  • EC-2.1.1.13
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 5-METHYL-THF-GLU-N[c] + 1 HOMO-CYS[c] => 1 THF-GLU-N[c] + 1 MET[c]
• With common name(s):
  • 1 an N5-methyl-tetrahydrofolate[c] + 1 L-homocysteine[c] => 1 a tetrahydrofolate[c] + 1 L-methionine[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Tiso_gene_1602
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: annotation-experimental_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus

Pathways

• PWY-3841, folate transformations II: PWY-3841
  • 9 reactions found over 11 reactions in the full pathway
• HOMOSER-METSYN-PWY, L-methionine biosynthesis I: HOMOSER-METSYN-PWY
  • 4 reactions found over 5 reactions in the full pathway
• 1CMET2-PWY, N10-formyl-tetrahydrofolate biosynthesis: 1CMET2-PWY
  • 7 reactions found over 9 reactions in the full pathway
• PWY-2201, folate transformations I: PWY-2201
  • 7 reactions found over 12 reactions in the full pathway
• HSERMETANA-PWY, L-methionine biosynthesis III: HSERMETANA-PWY
  • 3 reactions found over 4 reactions in the full pathway
• ADENOSYLHOMOCYSCAT-PWY, L-methionine salvage from L-homocysteine: ADENOSYLHOMOCYSCAT-PWY
  • 2 reactions found over 3 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-esiliculosus
    • Tool: pantograph
• Category: manual
  • Source: manual-primary_network
• Category: annotation
  • Source: annotation-experimental_annotation
    • Tool: pathwaytools
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools

External links

• RHEA:
  • 11172
• LIGAND-RXN:
  • R00946
• UNIPROT:
  • Q57195
  • Q9RVQ6
  • O33259
  • Q55786
  • Q09582
  • Q9Z2Q4
  • P13009