RXN-12705

Reaction RXN-12705

• direction:
  • LEFT-TO-RIGHT
• common name:
  • hydroxyacyl-coenzyme_a_dehydrogenase_3-ketoacyl-coenzyme_a_thiolase_enoyl-coenzyme_a_hydratasealpha_subunit
  • 3-hydroxyacyl-_dehydrogenase
  • hydroxyacyl-coenzyme_a_mitochondrial
• ec number:
  • EC-1.1.1.35
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 NAD[c] + 1 CPD-13694[c] => 1 CPD-13695[c] + 1 PROTON[c] + 1 NADH[c]
• With common name(s):
  • 1 NAD+[c] + 1 24-hydroxy-3-oxocholest-4-en-26-oyl-CoA[c] => 1 3,24-dioxocholest-4-en-26-oyl-CoA[c] + 1 H+[c] + 1 NADH[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Tiso_gene_18839
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_5857
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: annotation-experimental_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_14026
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: annotation-experimental_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_18838
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_14027
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_14262
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: annotation-experimental_annotation
    • Assignment: EC-NUMBER

Pathways

• PWY-6946, cholesterol degradation to androstenedione II (cholesterol dehydrogenase): PWY-6946
  • 3 reactions found over 22 reactions in the full pathway
• PWY-6945, cholesterol degradation to androstenedione I (cholesterol oxidase): PWY-6945
  • 2 reactions found over 17 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-esiliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-experimental_annotation
    • Tool: pathwaytools
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools