PWY-5856

Reaction 2.4.1.119-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • oligosaccharyl_transferase
• ec number:
  • EC-2.4.99.18
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 CPD-18076[c] + 1 Protein-L-Asparagine[c] => 1 CPD-224[c] + 1 PROTON[c] + 1 CPD-18077[c]
• With common name(s):
  • 1 α-D-Glc-(1→2)-α-D-Glc-(1→3)-α-D-Glc-(1→3)-α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol[c] + 1 a [protein]-L-asparagine[c] => 1 a dolichyl diphosphate[c] + 1 H+[c] + 1 a [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2][c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Tiso_gene_26
  • Source: annotation-experimental_annotation
    • Assignment: AUTOMATED-NAME-MATCH
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_10448
  • Source: annotation-in-silico_annotation
    • Assignment: AUTOMATED-NAME-MATCH
  • Source: orthology-esiliculosus

Pathways

• MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS, protein N-glycosylation (eukaryotic, high mannose): MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS
  • 19 reactions found over 19 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-esiliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools
  • Source: annotation-experimental_annotation
    • Tool: pathwaytools

External links

• UNIPROT:
  • P39656
  • P48440
  • P41543
  • P80896
  • P80897
  • P48439
  • P46964
  • Q92316
  • Q10176