RXN-13684

Reaction UBIQUITIN--PROTEIN-LIGASE-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • ORF
  • probable_e3_ubiquitin-protein_ligase_herc4_isoform_x10
  • peptidyl-prolyl_cis-trans_isomerase-like_2
  • low_quality_protein:_e3_ubiquitin-protein_ligase_herc2-like
  • e3_ubiquitin_ligase
  • zinc_finger_protein
  • o_ubiquitin_protein_ligase_e3a
  • f-box_only_protein_11
  • stackhouse_genomicscaffold_453
  • rab_family_gtpase
  • ubiquitin-protein_ligase
  • ubiquitin_protein_ligase
  • secretion-regulating_guanine_nucleotide_exchange
  • zinc_n-recogninwd40-like
  • auxin_transport_protein_isoform_2
  • f-box_lrr-repeat_protein_2
  • brca1-associated_ring_domain_protein_1
  • ankyrin_repeatdomain-containingprotein-50partial
  • ubiquitin-
  • phosphoglycerate_mutase_family_protein
  • wd_sam_and_u-box_domain_containing_1
  • anaphase_promoting_complex_subunit_11
  • tnf_receptor-associated_factor
  • e3_isg15--protein_ligase_herc6
  • hrd1-like_protein
  • os06g0159400_protein
  • f-box_lrr-repeat_protein
  • rni-like_protein
  • hect_e3_ubiquitin_ligase
  • regulator_of_chromosome_condensation_rcc1
  • probable_e3_ubiquitin-protein_ligase_herc4
• ec number:
  • EC-6.2.1.45
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 ATP[c] + 1 Ubiquitin-activating-protein-E1-L-cys[c] + 1 Ubiquitin-C-Terminal-Glycine[c] => 1 S-ubiquitinyl-UAP-E1-L-cysteine[c] + 1 AMP[c] + 1 PPI[c]
• With common name(s):
  • 1 ATP[c] + 1 an [E1 ubiquitin-activating enzyme]-L-cysteine[c] + 1 a [ubiquitin] C-terminal glycine[c] => 1 an S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine[c] + 1 AMP[c] + 1 diphosphate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Tiso_gene_13243
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_2815
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_6946
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_1585
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_13619
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_557
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_4966
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_3418
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_12309
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_2802
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_15097
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_1589
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_16913
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_9662
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_5776
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_17112
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_3210
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_3419
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_14650
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_4460
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_1588
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_7308
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_17517
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_1427
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_3211
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_18824
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_19647
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_4569
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_1590
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_6902
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_17030
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_11407
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_5502
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_7719
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_10888
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_12627
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_1583
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_8636
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_17363
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_1593
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_17194
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_16166
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_14182
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_4585
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_17004
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_2226
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_5622
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_16642
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_1592
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_9666
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_17195
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_14181
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_6910
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_8483
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_1587
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_8801
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_1586
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_11148
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_14567
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_7955
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_558
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_3081
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_10524
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_4484
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_4094
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_17423
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_1253
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_6903
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_15624
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_17196
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_18752
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_7506
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_15214
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_8048
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_12348
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_1335
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_1591
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_14360
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_12029
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_9575
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_4461
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_1584
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_7779
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_6901
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_1582
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_3080
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_1426
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_8637
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus

Pathways

• PWY-7511, protein ubiquitylation: PWY-7511
  • 9 reactions found over 9 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-esiliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools

External links

• LIGAND-RXN:
  • R03876
• UNIPROT:
  • P22314
  • P49459
  • P62256
  • P63146
  • P28263
  • Q02053
  • P62257
  • P61088
  • P63279
  • P19812
  • P21734
  • P25869
  • P31254
  • P15731
  • P15732
  • P29340
  • P35133
  • P35134
  • P35132
  • P33296
  • P22515
  • P39940
  • P42748
  • P42750
  • P42749
  • P42747
  • P50623
  • Q42973
  • P40984
  • Q92462
  • Q42540
  • P93028
  • P93393
  • P31252
  • P52486
  • Q9YGM6
  • O42646
  • O15979
  • P23566
  • Q96PU5
  • P27949