RXN1F-10

Reaction THYROXINE-DEIODINASE-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • type_i_iodothyronine_deiodinase
• ec number:
  • EC-1.21.99.4
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 L-THYROXINE[c] + 1 Donor-H2[c] => 1 CPD-387[c] + 1 PROTON[c] + 1 Acceptor[c] + 1 LIOTHYRONINE[c]
• With common name(s):
  • 1 L-thyroxine[c] + 1 a reduced electron acceptor[c] => 1 iodide[c] + 1 H+[c] + 1 an oxidized electron acceptor[c] + 1 3,5,3'-triiodo-L-thyronine[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Tiso_gene_20481
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER

Pathways

• PWY-6261, thyroid hormone metabolism II (via conjugation and/or degradation): PWY-6261
  • 11 reactions found over 15 reactions in the full pathway
• PWY-6260, thyroid hormone metabolism I (via deiodination): PWY-6260
  • 3 reactions found over 12 reactions in the full pathway

Reconstruction information

• Category: annotation
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools

External links

• RHEA:
  • 19745
• LIGAND-RXN:
  • R03734
• UNIPROT:
  • P21195
  • P49897
  • P49898
  • P05307
  • P09102
  • P07237
  • Q922C8
  • P04785
  • P24389