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	Ec number	Reconstruction category	Reconstruction tool	Reconstruction source	Gene associated	In pathway
ACYLCOADEHYDROG-RXN	EC-1.3.8	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 10643 Tiso gene 6475 Tiso gene 16113 Tiso gene 7447 Tiso gene 14511 Tiso gene 8272 Tiso gene 5449 Tiso gene 16631 Tiso gene 8271 Tiso gene 883 Tiso gene 6295	FAO-PWY
ACYLCOASYN-RXN	EC-6.2.1.3	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 7855 Tiso gene 13394 Tiso gene 348 Tiso gene 500 Tiso gene 10876 Tiso gene 9394 Tiso gene 136 Tiso gene 135 Tiso gene 4191	PWY-5136 PWY-7288 FAO-PWY PWY66-391
ACYLPHOSPHATASE-RXN	EC-3.6.1.7	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 13909
ADDALT-RXN	EC-3.5.4.4	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 19373 Tiso gene 18322	PWY-7179-1 PWY-7179
ADENODEAMIN-RXN	EC-3.5.4.4	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 18322 Tiso gene 19373	PWY0-1296 PWY-6609 PWY-6611 SALVADEHYPOX-PWY
ADENOSINE-KINASE-RXN	EC-2.7.1.20	Manual Annotation	Pathwaytools	Annotation-experimental annotation Manual-primary network Annotation-in-silico annotation	Tiso gene 12078	PWY-6619
ADENOSINE-NUCLEOSIDASE-RXN	EC-3.2.2.7	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 9396	PWY-6605
ADENOSYLHOMOCYSTEINASE-RXN	EC-3.3.1.1	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 14191	METHIONINE-DEG1-PWY PWY-5041
ADENYL-KIN-RXN	EC-2.7.4.3	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 694 Tiso gene 5837 Tiso gene 12257 Tiso gene 4816 Tiso gene 5839 Tiso gene 19036 Tiso gene 12256 Tiso gene 8576 Tiso gene 5387 Tiso gene 5081 Tiso gene 1453 Tiso gene 14116 Tiso gene 13477 Tiso gene 5388 Tiso gene 805 Tiso gene 3353 Tiso gene 19734	PWY-7219
ADENYLATECYC-RXN	EC-4.6.1.1	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-creinhardtii Orthology-esiliculosus	Tiso gene 13108 Tiso gene 8950 Tiso gene 9251 Tiso gene 1107 Tiso gene 16074 Tiso gene 34 Tiso gene 16294 Tiso gene 16143 Tiso gene 17342 Tiso gene 10744 Tiso gene 16542 Tiso gene 14301 Tiso gene 6404 Tiso gene 15744 Tiso gene 6871 Tiso gene 5483 Tiso gene 10495 Tiso gene 9865
ADENYLOSUCCINATE-SYNTHASE-RXN	EC-6.3.4.4	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 6453 Tiso gene 743	PWY-7219
ADENYLYLSULFATASE-RXN	EC-3.6.2.1	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 6339 Tiso gene 6338
ADPREDUCT-RXN	EC-1.17.4.1	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network	Tiso gene 10617 Tiso gene 9916 Tiso gene 10138 Tiso gene 9915	PWY-7220 PWY-7227
ADPSUGPPHOSPHAT-RXN	EC-3.6.1.21	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 7189
AICARSYN-RXN	EC-4.3.2.2	Manual Annotation	Pathwaytools	Manual-primary network Annotation-in-silico annotation		PWY-6123 PWY-6124 PWY-7234
AICARTRANSFORM-RXN	EC-2.1.2.3	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Manual-primary network Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 18420	PWY-6123 PWY-6124
AIRCARBOXY-RXN	EC-4.1.1.21	Orthology Manual Annotation	Pantograph Pathwaytools	Orthology-athaliana Annotation-in-silico annotation Manual-primary network Orthology-esiliculosus	Tiso gene 16011	PWY-6124
AIRS-RXN	EC-6.3.3.1	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Manual-primary network Annotation-in-silico annotation Orthology-synechocystis	Tiso gene 1369	PWY-6121 PWY-6122 PWY-6277
AKBLIG-RXN	EC-2.3.1.29	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 3555	THREONINE-DEG2-PWY
ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN	EC-2.6.1.44	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Manual-primary network Annotation-in-silico annotation Orthology-athaliana Orthology-esiliculosus	Tiso gene 11231 Tiso gene 6134 Tiso gene 5726	GLYSYN-ALA-PWY
ALANINE--TRNA-LIGASE-RXN	EC-6.1.1.7	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 2298 Tiso gene 3249 Tiso gene 18609 Tiso gene 19573 Tiso gene 18607	TRNA-CHARGING-PWY
ALANINE-AMINOTRANSFERASE-RXN	EC-2.6.1.2	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-athaliana Annotation-in-silico annotation Manual-primary network Orthology-esiliculosus	Tiso gene 5959 Tiso gene 10957	ALANINE-DEG3-PWY PWY-7383 PWY-7117 ALACAT2-PWY PWY-7115 ALANINE-SYN2-PWY
ALARACECAT-RXN	EC-5.1.1.1	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 20278	PWY-7383 ALANINE-VALINESYN-PWY ALADEG-PWY
ALCOHOL-DEHYDROG-GENERIC-RXN	EC-1.1.1.1	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 5424 Tiso gene 6563 Tiso gene 7649 Tiso gene 6562 Tiso gene 5425
ALCOHOL-DEHYDROG-RXN	EC-1.1.1.1	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-synechocystis	Tiso gene 5424 Tiso gene 6563 Tiso gene 5425 Tiso gene 7649 Tiso gene 18459 Tiso gene 6562	PWY66-21 PWY4LZ-257 PWY-7118 PWY-6587 PWY-6333 PWY-5486 P161-PWY ETOH-ACETYLCOA-ANA-PWY P122-PWY PWY-5480 FERMENTATION-PWY
ALCOHOL-O-ACETYLTRANSFERASE-RXN	EC-2.3.1.84	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 10528
ALDEHYDE-DEHYDROGENASE-NADORNOP+-RXN	EC-1.2.1.5	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 7322
ALDEHYDE-REDUCTASE-RXN	EC-1.1.1.21	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 8988 Tiso gene 7799 Tiso gene 18748 Tiso gene 7800
ALDOSE-1-EPIMERASE-RXN	EC-5.1.3.3	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-athaliana Annotation-in-silico annotation	Tiso gene 19779 Tiso gene 17734	PWY0-1466
ALDOSE1EPIM-RXN	EC-5.1.3.3	Annotation	Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation	Tiso gene 19779 Tiso gene 17734	PWY-6317 PWY66-422
ALKAPHOSPHA-RXN	EC-3.1.3.1	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 9372 Tiso gene 10738 Tiso gene 3271
ALLANTOICASE-RXN	EC-3.5.3.4	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 15504	PWY-5697
ALLANTOINASE-RXN	EC-3.5.2.5	Annotation	Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation		PWY-5697 PWY-5698
ALLYSINE-DEHYDROG-RXN	EC-1.2.1.31	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 5424 Tiso gene 6563 Tiso gene 5425 Tiso gene 6562 Tiso gene 16719
ALPHAGALACTOSID-RXN	EC-3.2.1.22	Orthology Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Orthology-athaliana Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 2588 Tiso gene 16101 Tiso gene 8673 Tiso gene 4615 Tiso gene 3392	PWY0-1301
AMIDASE-RXN	EC-3.5.1.4	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 13682
AMINOACYLASE-RXN	EC-3.5.1.14	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 16879
AMINOBUTDEHYDROG-RXN	EC-1.2.1.19	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 17322	PUTDEG-PWY PWY-2 PWY-3
AMINOCYL-TRNA-HYDROLASE-RXN	EC-3.1.1.29	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 7443 Tiso gene 13800 Tiso gene 14300
AMP-DEAMINASE-RXN	EC-3.5.4.17 EC-3.5.4.6	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 1778	PWY-6596
AMP-DEPHOSPHORYLATION-RXN	EC-3.1.3.5	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 6640 Tiso gene 14435 Tiso gene 6988 Tiso gene 14434 Tiso gene 13929 Tiso gene 5911 Tiso gene 14246	SALVADEHYPOX-PWY
AMPSYN-RXN	EC-4.3.2.2	Manual Annotation	Pathwaytools	Annotation-experimental annotation Manual-primary network Annotation-in-silico annotation		PWY-7219
ANTHRANSYN-RXN	EC-4.1.3.27	Orthology Manual Annotation	Pantograph Pathwaytools	Orthology-athaliana Annotation-in-silico annotation Manual-primary network Orthology-esiliculosus	Tiso gene 11176	TRPSYN-PWY PWY-5958 PWY-6661 PWY-6660
APIGNAR-RXN	EC-5.5.1.6	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 13414 Tiso gene 9838	PWY-7397 PWY1F-FLAVSYN PWY-6787
APYRASE-RXN	EC-3.6.1.5	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 12899 Tiso gene 20236
ARGINASE-RXN	EC-3.5.3.1	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-athaliana Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 4415	ARGASEDEG-PWY PWY-6922 ARG-PRO-PWY ARG-GLU-PWY PWY-4984 PWY-6305 CITRULBIO-PWY
ARGININE--TRNA-LIGASE-RXN	EC-6.1.1.19	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 12997 Tiso gene 16360	TRNA-CHARGING-PWY
ARGININE-2-MONOOXYGENASE-RXN	EC-1.13.12.1	Annotation	Pathwaytools	Annotation-in-silico annotation		ARGDEG-V-PWY
ARGSUCCINLYA-RXN	EC-4.3.2.1	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 2485	PWY-4984 ARGSYN-PWY PWY-5154 ARGSYNBSUB-PWY PWY-4983 PWY-7400
ARGSUCCINSYN-RXN	EC-6.3.4.5	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 12592	PWY-5154 ARGSYN-PWY PWY-4984 ARGSYNBSUB-PWY PWY-4983 PWY-7400

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