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	Common name	Ec number	Reconstruction category	Reconstruction tool	Reconstruction source	Gene associated	In pathway
3.4.22.68-RXN		EC-3.4.22.68	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 2617
3.4.23.1-RXN		EC-3.4.23.1	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 1894 Tiso gene 12450
3.4.24.11-RXN	Neutral endopeptidase	EC-3.4.24.11	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 15103
3.4.24.59-RXN	Mitochondrial intermediate peptidase	EC-3.4.24.59	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 10069
3.4.24.64-RXN	Mitochondrial processing peptidase	EC-3.4.24.64	Annotation	Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation	Tiso gene 5405
3.4.24.70-RXN		EC-3.4.24.70	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 4170
3.4.24.71-RXN	Endothelin-converting enzyme 1	EC-3.4.24.71	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 3765
3.4.25.1-RXN	26S protease regulatory subunit 7 26S protease regulatory subunit 8 homolog B	EC-3.4.25.1	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 19087 Tiso gene 1855 Tiso gene 16496 Tiso gene 11443 Tiso gene 18135 Tiso gene 3310 Tiso gene 11901 Tiso gene 5953 Tiso gene 7332 Tiso gene 20415 Tiso gene 2549
3.5.1.27-RXN	Polypeptide deformylase	EC-3.5.1.88	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 14998
3.5.1.52-RXN	Peptide-n4-(n-acetyl-beta-glucosaminyl)asparagine amidase	EC-3.5.1.52	Annotation	Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation	Tiso gene 18090 Tiso gene 18091
3.5.1.88-RXN	Polypeptide deformylase	EC-3.5.1.88	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 14998
3.5.1.98-RXN	Sir2-family protein hdac1 Histone deacetylase ORF Histone deacetylase 7a Histone deacetylase 1	EC-3.5.1.98	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 10459 Tiso gene 17880 Tiso gene 17340 Tiso gene 12946 Tiso gene 12131 Tiso gene 16490 Tiso gene 3315 Tiso gene 17377 Tiso gene 275 Tiso gene 18096 Tiso gene 727 Tiso gene 19850 Tiso gene 18920
3.5.2.17-RXN	5-hydroxyisourate hydrolase	EC-3.5.2.17	Orthology Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Annotation-in-silico annotation	Tiso gene 13181	PWY-7394 PWY-5691
3.5.5.1-RXN	Nitrilase	EC-3.5.5.1	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 10996
3.6.1.41-RXN	Metallophosphatase	EC-3.6.1.41	Orthology Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Annotation-in-silico annotation	Tiso gene 6311 Tiso gene 19348 Tiso gene 19347
3.6.3.1-RXN	ORF Haloacid dehalogenaselike hydrolase family protein Atpase	EC-3.6.3.1	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 13202 Tiso gene 7790 Tiso gene 13203 Tiso gene 13177 Tiso gene 11648 Tiso gene 7789
3.6.3.50-RXN		EC-3.6.3.50	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 6012 Tiso gene 8153 Tiso gene 15988 Tiso gene 11192 Tiso gene 10760 Tiso gene 11155 Tiso gene 5307 Tiso gene 1145 Tiso gene 11754 Tiso gene 9460 Tiso gene 1366 Tiso gene 1790 Tiso gene 2798 Tiso gene 12185 Tiso gene 11648 Tiso gene 7873 Tiso gene 12618 Tiso gene 18105
3.6.3.8-RXN	Calcium-transporting ATPase 1, endoplasmic reticulum-type	EC-3.6.3.8	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 10760
3.6.4.1-RXN	Myosin atpase	EC-3.6.4.1	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 8826 Tiso gene 9060
3.6.4.4-RXN	Kinesin	EC-3.6.4.4	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 9800 Tiso gene 16240 Tiso gene 18523 Tiso gene 12881 Tiso gene 15652 Tiso gene 14940 Tiso gene 1492 Tiso gene 5584 Tiso gene 2393 Tiso gene 10834 Tiso gene 10355 Tiso gene 10356 Tiso gene 646 Tiso gene 14941 Tiso gene 6071
3.6.4.6-RXN	Vesicle-fusing ATPase	EC-3.6.4.6	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 1145
3.6.4.9-RXN			Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 1384
3.8.1.11-RXN	Had family hydrolase	EC-3.8.1.11	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 3200
325-BISPHOSPHATE-NUCLEOTIDASE-RXN		EC-3.1.3.7	Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 12601
34HPPYRI	3-(4-Hydroxyphenyl)pyruvate keto-enol-isomerase		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 5011
35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN		EC-3.1.4.35	Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 9644 Tiso gene 13785 Tiso gene 12792
3PG pi thr	3-Phospho-D-glycerate transport via triose phosphate translocator (from chloroplast)		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 5890 Tiso gene 6426 Tiso gene 17661
3PGAREARR-RXN	Phosphoglycerate mutase Bisphosphoglycerate-dependent phosphoglycerate mutase ORF Plastid phosphoglycerate mutase protein	EC-5.4.2.12	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 16271 Tiso gene 5468 Tiso gene 14530 Tiso gene 7201 Tiso gene 20311 Tiso gene 2365 Tiso gene 10516 Tiso gene 16754 Tiso gene 9922 Tiso gene 2667 Tiso gene 15391 Tiso gene 2841 Tiso gene 15048 Tiso gene 14212 Tiso gene 9923 Tiso gene 14664	PWY-1042 P341-PWY PWY-2221 GLUCONEO-PWY GLYCOLYSIS PWY-6901 PWY-7218 P124-PWY PWY-6886 PWY-5723 PWY-6142 PWY-5484 PWY-7124 PWY-7003
4-COUMARATE--COA-LIGASE-RXN		EC-6.2.1.12	Orthology	Pantograph	Orthology-athaliana Orthology-esiliculosus	Tiso gene 12275 Tiso gene 14183	PWY-6920 PWY-6435 PWY-7398 PWY-7046 PWY-361 PWY-7397 PWY-6320 PWY1F-FLAVSYN PWY-5754 PWY-5135 PWY-6982
4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN		EC-4.1.2.52	Orthology	Pantograph	Orthology-athaliana Orthology-esiliculosus	Tiso gene 13940	3-HYDROXYPHENYLACETATE-DEGRADATION-PWY
4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN	Probable gamma hydroxybutyrate dehydrogenase Gamma hydroxybutyrate dehydrogenase	EC-1.1.1.61	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 777 Tiso gene 91	PWY-5022 PWY-5677
4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN	4-hydroxyphenylpyruvate dioxygenase ORF	EC-1.13.11.27	Orthology Annotation	Pantograph Pathwaytools	Orthology-athaliana Annotation-in-silico annotation Orthology-synechocystis Orthology-esiliculosus	Tiso gene 18328 Tiso gene 18976 Tiso gene 18977	PWY-1581 PWY-7432 TYRFUMCAT-PWY PWY-1422
4-NITROPHENYLPHOSPHATASE-RXN	Phosphoglycolate phosphatase 2 ORF	EC-3.1.3.41	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 5996 Tiso gene 442 Tiso gene 6690 Tiso gene 18054 Tiso gene 15176 Tiso gene 6236 Tiso gene 15559 Tiso gene 18651 Tiso gene 6980 Tiso gene 15498
4.1.2.20-RXN	2-dehydro-3-deoxyglucarate aldolase	EC-4.1.2.20	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 16237
4.1.99.4-RXN		EC-3.5.99.7	Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 11198
4.2.1.58-RXN	Polyketide synthase Β-hydroxybutyryl acyl carrier protein (ACP) dehydrase Β-hydroxybutyryl acyl carrier protein dehydrase Enoyl acyl carrier protein hydrase Crotonyl acyl carrier protein hydratase 3-hydroxybutyryl acyl carrier protein dehydratase	EC-2.3.1.86 EC-2.3.1.85 EC-4.2.1.59	Manual Annotation	Pathwaytools	Annotation-experimental annotation Manual-primary network Annotation-in-silico annotation	Tiso gene 6884 Tiso gene 13394 Tiso gene 136 Tiso gene 500 Tiso gene 135 Tiso gene 10876	PWY-5971 PWY-5994 PWY-7388
4.2.1.59-RXN	Polyketide synthase	EC-2.3.1.86 EC-2.3.1.85 EC-4.2.1.59	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Manual-primary network Annotation-experimental annotation Orthology-synechocystis	Tiso gene 500 Tiso gene 13394 Tiso gene 10876 Tiso gene 135 Tiso gene 6884 Tiso gene 6885 Tiso gene 136	PWY-5971 PWY-5994
4.2.1.61-RXN	Polyketide synthase Β-hydroxypalmitoyl-acyl carrier protein dehydrase Β-hydroxypalmitoyl thioester dehydratase Β-hydroxypalmityl-ACP dehydrase	EC-2.3.1.86 EC-2.3.1.85 EC-4.2.1.59	Manual Annotation	Pathwaytools	Annotation-in-silico annotation Manual-primary network Annotation-experimental annotation	Tiso gene 136 Tiso gene 13394 Tiso gene 10876 Tiso gene 500 Tiso gene 6884 Tiso gene 135	PWY-5971 PWY-5994
4.2.2.10-RXN		EC-4.2.2.10	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 12495 Tiso gene 1435 Tiso gene 4393 Tiso gene 13619 Tiso gene 3975 Tiso gene 3396 Tiso gene 3374 Tiso gene 3904 Tiso gene 10323
4.2.99.18-RXN	Formamidopyrimidine-dna glycosylase Endonuclease iii Dna-(apurinic or apyrimidinic site) lyase	EC-4.2.99.18	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 1280 Tiso gene 5102 Tiso gene 14609 Tiso gene 6558 Tiso gene 17380
4.3.1.17-RXN		EC-4.3.1.17	Orthology Manual	Pantograph	Manual-primary network Orthology-creinhardtii Orthology-synechocystis	Tiso gene 12535
4.4.1.14-RXN	1-aminocyclopropane-1-carboxylate synthase	EC-4.4.1.14	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-athaliana Orthology-creinhardtii Orthology-esiliculosus	Tiso gene 8455	ETHYL-PWY PWY-7270
4OH2OXOGLUTARALDOL-RXN		EC-4.1.3.16	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 12620	HYDROXYPRODEG-PWY
4OHBENZOATE-OCTAPRENYLTRANSFER-RXN	4-hydroxybenzoate octaprenyltransferase	EC-2.5.1.39	Annotation	Pathwaytools	Annotation-in-silico annotation	Tiso gene 4719	PWY-6708 PWY-5870
5-NUCLEOTID-RXN	5 -nucleotidase 5 deoxy cytosolic type c protein Probable cytosolic imp-gmp specific 5 -nucleotidase ORF	EC-3.1.3.5	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 6988 Tiso gene 13929 Tiso gene 14435 Tiso gene 5911 Tiso gene 6640 Tiso gene 14434 Tiso gene 14246
5-OXOPROLINASE-ATP-HYDROLYSING-RXN	5-oxoprolinase	EC-3.5.2.9	Orthology Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Orthology-athaliana Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 3358 Tiso gene 3359	PWY-4041
5.1.1.16-RXN		EC-5.1.1.16	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 17207
5.1.1.18-RXN		EC-5.1.1.18	Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 17207	PWY-6455 PWY-6196
5.3.1.23-RXN		EC-5.3.1.23	Orthology	Pantograph	Orthology-synechocystis	Tiso gene 18341 Tiso gene 3805	PWY-7174 PWY-4361
5.3.4.1-RXN	Nucleoredoxin ORF Probable protein disulfide-isomerase	EC-5.3.4.1	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 15704 Tiso gene 475 Tiso gene 4246 Tiso gene 4244 Tiso gene 7350 Tiso gene 14313

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