RXN66-521

Reaction RXN-12583

• direction:
  • LEFT-TO-RIGHT
• common name:
  • pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
  • pyruvate_dehydrogenase_e1_component_subunit_alpha-_mitochondrial
  • dihydrolipoamide_acetyltransferase
  • ORF
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 PYRUVATE[c] + 1 THIAMINE-PYROPHOSPHATE[c] + 1 PROTON[c] => 1 CARBON-DIOXIDE[c] + 1 2-ALPHA-HYDROXYETHYL-THPP[c]
• With common name(s):
  • 1 pyruvate[c] + 1 thiamine diphosphate[c] + 1 H+[c] => 1 CO2[c] + 1 2-(α-hydroxyethyl)thiamine diphosphate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Tiso_gene_7519
  • IN-SILICO_ANNOTATION
    • EC-NUMBER
  • pantograph-esiliculosus
• Tiso_gene_2693
  • IN-SILICO_ANNOTATION
    • EC-NUMBER
  • EXPERIMENTAL_ANNOTATION
    • EC-NUMBER
• Tiso_gene_11362
  • pantograph-athaliana
• Tiso_gene_2515
  • EXPERIMENTAL_ANNOTATION
    • EC-NUMBER
  • pantograph-athaliana
  • pantograph-esiliculosus
• Tiso_gene_17539
  • EXPERIMENTAL_ANNOTATION
    • EC-NUMBER
  • pantograph-esiliculosus
• Tiso_gene_6983
  • IN-SILICO_ANNOTATION
    • EC-NUMBER
  • EXPERIMENTAL_ANNOTATION
    • EC-NUMBER
  • pantograph-athaliana
  • pantograph-esiliculosus

Reconstruction information

• orthology:
  • pantograph:
    • athaliana
    • esiliculosus
• annotation:
  • pathwaytools:
    • experimental_annotation
    • in-silico_annotation

External links

• LIGAND-RXN:
  • R00014