CPD-9869

Reaction PYRROLINECARBREDUCT-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • pyrroline-5-carboxylate_reductase
  • ORF
  • ankyrin_repeat-containing_protein
• ec number:
  • EC-1.5.1.2
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 L-DELTA1-PYRROLINE_5-CARBOXYLATE[c] + 1 NADH-P-OR-NOP[c] + 2 PROTON[c] => 1 PRO[c] + 1 NAD-P-OR-NOP[c]
• With common name(s):
  • 1 (S)-1-pyrroline-5-carboxylate[c] + 1 NAD(P)H[c] + 2 H+[c] => 1 L-proline[c] + 1 NAD(P)+[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Tiso_gene_8625
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: annotation-experimental_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_20218
  • Source: annotation-in-silico_annotation
    • Assignment: AUTOMATED-NAME-MATCH
• Gene: Tiso_gene_19254
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_17059
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER

Pathways

• PROSYN-PWY, L-proline biosynthesis I: PROSYN-PWY
  • 4 reactions found over 4 reactions in the full pathway
• ARG-PRO-PWY, L-arginine degradation VI (arginase 2 pathway): ARG-PRO-PWY
  • 4 reactions found over 4 reactions in the full pathway
• PWY-6344, L-ornithine degradation II (Stickland reaction): PWY-6344
  • 4 reactions found over 9 reactions in the full pathway
• PWY-4981, L-proline biosynthesis II (from arginine): PWY-4981
  • 4 reactions found over 6 reactions in the full pathway
• PWY-3341, L-proline biosynthesis III: PWY-3341
  • 5 reactions found over 5 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-esiliculosus
    • Tool: pantograph
• Category: manual
  • Source: manual-primary_network
• Category: annotation
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools
  • Source: annotation-experimental_annotation
    • Tool: pathwaytools

External links

• LIGAND-RXN:
  • R01248
  • R01251
• UNIPROT:
  • P32322
  • P27771
  • Q9CEF7
  • P14383
  • Q9PNL8
  • Q9JWW2
  • Q12740
  • P22008
  • P54904
  • P0A9L8
  • P17817
  • P32263
  • Q12641
  • P46725
  • P74572
  • Q04708