RXN-17730

Reaction GCVT-RXN

• direction:
  • REVERSIBLE
• common name:
  • dimethylglycine_dehydrogenase
  • aminomethyltransferase
  • glycine_cleavage_t-protein_c-terminal_barrel_domain
  • sarcosine_dehydrogenase
• ec number:
  • EC-2.1.2.10
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 AMINOMETHYLDIHYDROLIPOYL-GCVH[c] + 1 THF-GLU-N[c] <=> 1 AMMONIUM[c] + 1 DIHYDROLIPOYL-GCVH[c] + 1 METHYLENE-THF-GLU-N[c]
• With common name(s):
  • 1 a [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine[c] + 1 a tetrahydrofolate[c] <=> 1 ammonium[c] + 1 a [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine[c] + 1 a 5,10-methylene-tetrahydrofolate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Tiso_gene_2717
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_17287
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: annotation-experimental_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_15700
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_19389
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: annotation-experimental_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_6882
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_14788
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER

Pathways

• GLYCLEAV-PWY, glycine cleavage: GLYCLEAV-PWY
  • 3 reactions found over 3 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-esiliculosus
    • Tool: pantograph
• Category: manual
  • Source: manual-primary_network
• Category: annotation
  • Source: annotation-experimental_annotation
    • Tool: pathwaytools
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools

External links

• RHEA:
  • 16945
• LIGAND-RXN:
  • R04125
• UNIPROT:
  • P25285
  • P28337
  • P27248
  • Q9UZP8
  • Q9JVP2
  • P48728
  • P49364
  • P49095
  • P49363
  • P54260
  • P49361
  • P49362
  • O49954
  • P93256
  • O32955