4.2.99.18-RXN

Reaction AICARTRANSFORM-RXN

• direction:
  • REVERSIBLE
• common name:
  • bifunctional_purine_biosynthesis
• ec number:
  • EC-2.1.2.3
• Synonym(s):
  • 5-aminoimidazole-4-carboxamide ribonucleotide transformylase

Reaction Formula

• With identifiers:
  • 1 FORMYL-THF-GLU-N[c] + 1 AICAR[c] <=> 1 PHOSPHORIBOSYL-FORMAMIDO-CARBOXAMIDE[c] + 1 THF-GLU-N[c]
• With common name(s):
  • 1 an N10-formyl-tetrahydrofolate[c] + 1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide[c] <=> 1 5-formamido-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide[c] + 1 a tetrahydrofolate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Tiso_gene_18420
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: annotation-experimental_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus

Pathways

• PWY-6123, inosine-5'-phosphate biosynthesis I: PWY-6123
  • 5 reactions found over 6 reactions in the full pathway
• PWY-6124, inosine-5'-phosphate biosynthesis II: PWY-6124
  • 5 reactions found over 5 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-esiliculosus
    • Tool: pantograph
• Category: manual
  • Source: manual-primary_network
• Category: annotation
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools
  • Source: annotation-experimental_annotation
    • Tool: pathwaytools

External links

• RHEA:
  • 22192
• LIGAND-RXN:
  • R04560
• UNIPROT:
  • P43852
  • P12048
  • P31335
  • P26978
  • P15639
  • Q9PNY2
  • Q9JUQ8
  • P31939
  • Q59493
  • P38009
  • P54113
  • O64767
  • O74928