RXN-12583

Reaction RXN-12583

• direction:
  • LEFT-TO-RIGHT
• common name:
  • pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
  • pyruvate_dehydrogenase_e1_component_subunit_alpha-_mitochondrial
  • dihydrolipoamide_acetyltransferase
  • ORF
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 PROTON[c] + 1 THIAMINE-PYROPHOSPHATE[c] + 1 PYRUVATE[c] => 1 CARBON-DIOXIDE[c] + 1 2-ALPHA-HYDROXYETHYL-THPP[c]
• With common name(s):
  • 1 H+[c] + 1 thiamine diphosphate[c] + 1 pyruvate[c] => 1 CO2[c] + 1 2-(α-hydroxyethyl)thiamine diphosphate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Tiso_gene_7519
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_17539
  • Source: annotation-experimental_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_6983
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: annotation-experimental_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-athaliana
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_11362
  • Source: orthology-athaliana
• Gene: Tiso_gene_2515
  • Source: annotation-experimental_annotation
    • Assignment: EC-NUMBER
  • Source: orthology-athaliana
  • Source: orthology-esiliculosus
• Gene: Tiso_gene_2693
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: annotation-experimental_annotation
    • Assignment: EC-NUMBER

Reconstruction information

• Category: orthology
  • Source: orthology-athaliana
    • Tool: pantograph
  • Source: orthology-esiliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools
  • Source: annotation-experimental_annotation
    • Tool: pathwaytools

External links

• LIGAND-RXN:
  • R00014