RXN-12362

Reaction HEME-OXYGENASE-DECYCLIZING-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • ORF
• ec number:
  • EC-1.14.14.18
• Synonym(s):

Reaction Formula

• With identifiers:
  • 2 PROTON[c] + 3 OXYGEN-MOLECULE[c] + 3 Red-NADPH-Hemoprotein-Reductases[c] + 1 PROTOHEME[c] => 3 WATER[c] + 1 FE+2[c] + 1 BILIVERDINE[c] + 3 Ox-NADPH-Hemoprotein-Reductases[c] + 1 CARBON-MONOXIDE[c]
• With common name(s):
  • 2 H+[c] + 3 oxygen[c] + 3 a reduced [NADPH-hemoprotein reductase][c] + 1 ferroheme b[c] => 3 H2O[c] + 1 Fe2+[c] + 1 biliverdin-IX-α[c] + 3 an oxidized [NADPH-hemoprotein reductase][c] + 1 carbon monoxide[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Tiso_gene_19364
  • IN-SILICO_ANNOTATION
    • EC-NUMBER

Pathways

• PWY-5874, heme degradation: PWY-5874
  • 2 reactions found over 2 reactions in the full pathway

Reconstruction information

• annotation:
  • pathwaytools:
    • in-silico_annotation

External links

• LIGAND-RXN:
  • R00311
• UNIPROT:
  • P23711
  • P14901
  • P30519
  • P06762
  • P09601
  • Q7M338
  • P14791
  • P32394
  • P72849
  • P74133
  • Q9RKR1
  • O48782